登録情報 | データベース: PDB / ID: 2l2t |
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タイトル | Solution NMR structure of the ErbB4 dimeric membrane domain |
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要素 | Receptor tyrosine-protein kinase erbB-4 |
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キーワード | MEMBRANE PROTEIN / ErbB4 / transmembrane dimer / membrane domain |
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機能・相同性 | 機能・相同性情報
establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / neuregulin receptor activity / cardiac muscle tissue regeneration / ERBB2-ERBB4 signaling pathway / mitochondrial fragmentation involved in apoptotic process ...establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / neuregulin receptor activity / cardiac muscle tissue regeneration / ERBB2-ERBB4 signaling pathway / mitochondrial fragmentation involved in apoptotic process / ERBB2 Activates PTK6 Signaling / GABA receptor binding / PI3K events in ERBB4 signaling / mammary gland epithelial cell differentiation / embryonic pattern specification / Signaling by ERBB4 / positive regulation of protein localization to cell surface / ERBB2 Regulates Cell Motility / PI3K events in ERBB2 signaling / neural crest cell migration / neurotransmitter receptor localization to postsynaptic specialization membrane / epidermal growth factor receptor binding / cell fate commitment / cell surface receptor signaling pathway via JAK-STAT / Long-term potentiation / cellular response to epidermal growth factor stimulus / Signaling by ERBB2 / SHC1 events in ERBB4 signaling / GABA-ergic synapse / mammary gland alveolus development / GRB2 events in ERBB2 signaling / transmembrane receptor protein tyrosine kinase activity / neurogenesis / SHC1 events in ERBB2 signaling / basal plasma membrane / Nuclear signaling by ERBB4 / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of cardiac muscle cell proliferation / cell surface receptor protein tyrosine kinase signaling pathway / synapse assembly / Downregulation of ERBB4 signaling / lactation / regulation of cell migration / Signaling by ERBB2 TMD/JMD mutants / Signaling by ERBB2 KD Mutants / receptor protein-tyrosine kinase / Downregulation of ERBB2 signaling / positive regulation of receptor signaling pathway via JAK-STAT / postsynaptic density membrane / neuromuscular junction / peptidyl-tyrosine phosphorylation / Constitutive Signaling by Aberrant PI3K in Cancer / PIP3 activates AKT signaling / cell migration / nervous system development / presynaptic membrane / heart development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / basolateral plasma membrane / protein tyrosine kinase activity / postsynaptic membrane / Estrogen-dependent gene expression / protein autophosphorylation / transcription cis-regulatory region binding / receptor complex / positive regulation of ERK1 and ERK2 cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / mitochondrial matrix / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / positive regulation of cell population proliferation / glutamatergic synapse / positive regulation of DNA-templated transcription / negative regulation of apoptotic process / signal transduction / protein homodimerization activity / mitochondrion / extracellular region / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol類似検索 - 分子機能 Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #880 / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #880 / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Growth factor receptor cysteine-rich domain superfamily / : / Helix non-globular / Special / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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Model details | lowest energy, model 1 |
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データ登録者 | Mineev, K.S. / Bocharov, E.V. / Goncharuk, M.V. / Arseniev, A.S. |
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引用 | ジャーナル: Biochim. Biophys. Acta / 年: 2012 タイトル: Structural and thermodynamic insight into the process of "weak" dimerization of the ErbB4 transmembrane domain by solution NMR. 著者: Bocharov, E.V. / Mineev, K.S. / Goncharuk, M.V. / Arseniev, A.S. |
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履歴 | 登録 | 2010年8月27日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2011年9月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月6日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.model |
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