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- PDB-2l00: Solution structure of the non-covalent complex of the ZNF216 A20 ... -
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Basic information
Entry | Database: PDB / ID: 2l00 | ||||||
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Title | Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin | ||||||
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![]() | METAL BINDING PROTEIN/PEPTIDE BINDING PROTEIN / A20 domain / ZNF216 / ubiquitin / zinc finger / ubiquitin binding / METAL BINDING PROTEIN-PEPTIDE BINDING PROTEIN complex | ||||||
Function / homology | ![]() : / : / : / : / : / Regulation of TP53 Degradation / Josephin domain DUBs / RAS processing / Regulation of PTEN localization / ER Quality Control Compartment (ERQC) ...: / : / : / : / : / Regulation of TP53 Degradation / Josephin domain DUBs / RAS processing / Regulation of PTEN localization / ER Quality Control Compartment (ERQC) / UCH proteinases / Pexophagy / Interleukin-1 signaling / Aggrephagy / Regulation of pyruvate metabolism / Peroxisomal protein import / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / ABC-family proteins mediated transport / Metalloprotease DUBs / Endosomal Sorting Complex Required For Transport (ESCRT) / E3 ubiquitin ligases ubiquitinate target proteins / respiratory system process / smooth muscle tissue development / Translesion Synthesis by POLH / fibroblast migration / Translesion synthesis by REV1 / Translesion synthesis by POLK / Translesion synthesis by POLI / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Termination of translesion DNA synthesis / Negative regulators of DDX58/IFIH1 signaling / vasculature development / skeletal system morphogenesis / Formation of the ternary complex, and subsequently, the 43S complex / Ribosomal scanning and start codon recognition / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / Formation of TC-NER Pre-Incision Complex / Major pathway of rRNA processing in the nucleolus and cytosol / Orc1 removal from chromatin / face development / MAPK6/MAPK4 signaling / SRP-dependent cotranslational protein targeting to membrane / GTP hydrolysis and joining of the 60S ribosomal subunit / Gap-filling DNA repair synthesis and ligation in TC-NER / Formation of a pool of free 40S subunits / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Antigen processing: Ubiquitination & Proteasome degradation / L13a-mediated translational silencing of Ceruloplasmin expression / platelet-derived growth factor receptor signaling pathway / Dual incision in TC-NER / ribosomal large subunit export from nucleus / Ub-specific processing proteases / ribosomal large subunit assembly / modification-dependent protein catabolic process / protein tag activity / ribosome biogenesis / peroxisome / in utero embryonic development / cytosolic large ribosomal subunit / cytoplasmic translation / protein ubiquitination / structural constituent of ribosome / ubiquitin protein ligase binding / DNA binding / zinc ion binding / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() ![]() | ||||||
Method | SOLUTION NMR / Rigid Body Docking, molecular dynamics | ||||||
Model details | lowest energy, model 1 | ||||||
![]() | Garner, T.P. / Long, J.E. / Searle, M.S. / Layfield, R. | ||||||
![]() | ![]() Title: Co-localisation of ubiquitin receptors ZNF216 and p62 in a ubiquitin-mediated ternary complex Authors: Garner, T.P. / Strachan, J. / Long, J.E. / Layfield, R. / Searle, M.S. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 330.8 KB | Display | ![]() |
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PDB format | ![]() | 272.6 KB | Display | ![]() |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 2kzyC C: citing same article ( |
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Similar structure data | |
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 6538.265 Da / Num. of mol.: 1 / Fragment: A20 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() |
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#2: Protein | Mass: 8568.769 Da / Num. of mol.: 1 / Fragment: ubiquitin core domain Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() Gene: PUBI-2, UBI1 / Production host: ![]() ![]() |
#3: Chemical | ChemComp-ZN / |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR Details: NMR derived solution structure of the A20 zinc finger of ZNF216 with ubiquitin derived from NOE, PRE and RDC measurements | ||||||||||||||||||||||||||||||||||||||||||||
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Sample preparation
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