- PDB-2kzt: Structure of the Tandem MA-3 Region of Pdcd4 -
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基本情報
登録情報
データベース: PDB / ID: 2kzt
タイトル
Structure of the Tandem MA-3 Region of Pdcd4
要素
(Programmed cell death protein 4) x 2
キーワード
APOPTOSIS / Pdcd4 / MA-3 / eIF4A / HEAT
機能・相同性
機能・相同性情報
epithelial to mesenchymal transition involved in cardiac fibroblast development / negative regulation of myofibroblast differentiation / negative regulation of vascular associated smooth muscle cell differentiation / positive regulation of smooth muscle cell apoptotic process / negative regulation of JUN kinase activity / regulation of protein metabolic process / positive regulation of endothelial cell apoptotic process / response to alkaloid / positive regulation of vascular associated smooth muscle cell apoptotic process / negative regulation of vascular associated smooth muscle cell proliferation ...epithelial to mesenchymal transition involved in cardiac fibroblast development / negative regulation of myofibroblast differentiation / negative regulation of vascular associated smooth muscle cell differentiation / positive regulation of smooth muscle cell apoptotic process / negative regulation of JUN kinase activity / regulation of protein metabolic process / positive regulation of endothelial cell apoptotic process / response to alkaloid / positive regulation of vascular associated smooth muscle cell apoptotic process / negative regulation of vascular associated smooth muscle cell proliferation / negative regulation of cytokine production involved in inflammatory response / BMP signaling pathway / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / response to hormone / positive regulation of inflammatory response / positive regulation of non-canonical NF-kappaB signal transduction / cellular response to lipopolysaccharide / negative regulation of DNA-templated transcription / apoptotic process / negative regulation of apoptotic process / RNA binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
Programmed cell death protein 4 / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #180 / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha 類似検索 - ドメイン・相同性
Programmed cell death protein 4 / Programmed cell death protein 4 類似検索 - 構成要素
手法: 溶液NMR 詳細: Structure of the tandem MA-3 region of Pdcd4, obtained by docking the structures of the individual domains (PDB 2RG8 and 2HM8) using HADDOCK