- PDB-2kzt: Structure of the Tandem MA-3 Region of Pdcd4 -
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Basic information
Entry
Database: PDB / ID: 2kzt
Title
Structure of the Tandem MA-3 Region of Pdcd4
Components
(Programmed cell death protein 4) x 2
Keywords
APOPTOSIS / Pdcd4 / MA-3 / eIF4A / HEAT
Function / homology
Function and homology information
epithelial to mesenchymal transition involved in cardiac fibroblast development / negative regulation of myofibroblast differentiation / negative regulation of vascular associated smooth muscle cell differentiation / positive regulation of smooth muscle cell apoptotic process / negative regulation of JUN kinase activity / regulation of protein metabolic process / positive regulation of endothelial cell apoptotic process / response to alkaloid / positive regulation of vascular associated smooth muscle cell apoptotic process / negative regulation of vascular associated smooth muscle cell proliferation ...epithelial to mesenchymal transition involved in cardiac fibroblast development / negative regulation of myofibroblast differentiation / negative regulation of vascular associated smooth muscle cell differentiation / positive regulation of smooth muscle cell apoptotic process / negative regulation of JUN kinase activity / regulation of protein metabolic process / positive regulation of endothelial cell apoptotic process / response to alkaloid / positive regulation of vascular associated smooth muscle cell apoptotic process / negative regulation of vascular associated smooth muscle cell proliferation / negative regulation of cytokine production involved in inflammatory response / BMP signaling pathway / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / response to hormone / positive regulation of inflammatory response / positive regulation of non-canonical NF-kappaB signal transduction / cellular response to lipopolysaccharide / negative regulation of DNA-templated transcription / apoptotic process / negative regulation of apoptotic process / RNA binding / nucleus / cytoplasm / cytosol Similarity search - Function
Programmed cell death protein 4 / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #180 / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha Similarity search - Domain/homology
Programmedcelldeathprotein4 / Pdcd4 / Nuclear antigen H731-like / Neoplastic transformation inhibitor protein / Protein 197/15a
Mass: 17653.211 Da / Num. of mol.: 1 / Fragment: MA-3 Region, residues 157-318 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli) / Strain (production host): BL21 (DE3) / References: UniProt: Q53EL6
#2: Protein
Programmedcelldeathprotein4 / Pdcd4 / Topoisomerase-inhibitor suppressed protein / Protein MA-3
Mass: 15093.329 Da / Num. of mol.: 1 / Fragment: MA-3 Region, residues 319-449 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli (E. coli) / Strain (production host): BL21 (DE3) / References: UniProt: Q61823
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR Details: Structure of the tandem MA-3 region of Pdcd4, obtained by docking the structures of the individual domains (PDB 2RG8 and 2HM8) using HADDOCK
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