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- PDB-2kze: Structure of an all-parallel-stranded G-quadruplex formed by hTER... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2kze | ||||||||||||||||||||
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Title | Structure of an all-parallel-stranded G-quadruplex formed by hTERT promoter sequence | ||||||||||||||||||||
![]() | DNA (5'-D(*![]() DNA / anticancer targets / G-quadruplex / hTERT promoter / telomerase inhibition | Function / homology | DNA / DNA (> 10) | ![]() Method | SOLUTION NMR / DGSA-distance geometry simulated annealing, distance-restrained molecular dynamics | Model details | lowest energy, model 1 | ![]() Lim, K.W. / Lacroix, L. / Yue, D.J.E. / Lim, J.K.C. / Lim, J.M.W. / Phan, A.T. | ![]() ![]() Title: Coexistence of two distinct G-quadruplex conformations in the hTERT promoter Authors: Lim, K.W. / Lacroix, L. / Yue, D.J.E. / Lim, J.K.C. / Lim, J.M.W. / Phan, A.T. History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 137.8 KB | Display | ![]() |
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PDB format | ![]() | 114.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 307.5 KB | Display | ![]() |
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Full document | ![]() | 361 KB | Display | |
Data in XML | ![]() | 5.3 KB | Display | |
Data in CIF | ![]() | 8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: DNA chain | Mass: 6356.074 Da / Num. of mol.: 1 / Source method: obtained synthetically |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details |
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Sample |
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Sample conditions | Ionic strength: 90mM K+ / pH: 7 / Pressure: ambient / Temperature: 298 K |
-NMR measurement
NMR spectrometer |
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Processing
NMR software |
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Refinement | Method: DGSA-distance geometry simulated annealing, distance-restrained molecular dynamics Software ordinal: 1 | ||||||||||||||||||||
NMR constraints | NA chi-angle constraints total count: 12 / NA epsilon-angle constraints total count: 8 / NA other-angle constraints total count: 12 / NOE constraints total: 470 / Hydrogen bond constraints total count: 48 | ||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 10 / Maximum lower distance constraint violation: 0.172 Å / Maximum upper distance constraint violation: 0.128 Å / Representative conformer: 1 | ||||||||||||||||||||
NMR ensemble rms | Distance rms dev: 0.015 Å / Distance rms dev error: 0.001 Å |