登録情報 データベース : PDB / ID : 2kne 構造の表示 ダウンロードとリンクタイトル Calmodulin wraps around its binding domain in the plasma membrane CA2+ pump anchored by a novel 18-1 motif 要素ATPase, Ca++ transporting, plasma membrane 4 Calmodulin 詳細キーワード METAL TRANSPORT / protein/peptide / calcium pump / calmodulin / Acetylation / Calcium / Isopeptide bond / Methylation / Phosphoprotein / Polymorphism / Ubl conjugation / ATP-binding / Hydrolase / Membrane / Nucleotide-binding / Transmembrane機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of the force of heart contraction / negative regulation of arginine catabolic process / negative regulation of cellular response to vascular endothelial growth factor stimulus / negative regulation of citrulline biosynthetic process / calcium ion transmembrane transporter activity / : / cellular response to acetylcholine / negative regulation of nitric oxide mediated signal transduction / nitric-oxide synthase inhibitor activity / negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ... negative regulation of the force of heart contraction / negative regulation of arginine catabolic process / negative regulation of cellular response to vascular endothelial growth factor stimulus / negative regulation of citrulline biosynthetic process / calcium ion transmembrane transporter activity / : / cellular response to acetylcholine / negative regulation of nitric oxide mediated signal transduction / nitric-oxide synthase inhibitor activity / negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process / negative regulation of peptidyl-cysteine S-nitrosylation / negative regulation of nitric-oxide synthase activity / negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway / sperm principal piece / calcium ion export / response to hydrostatic pressure / regulation of sodium ion transmembrane transport / flagellated sperm motility / P-type Ca2+ transporter / neural retina development / : / regulation of cell cycle G1/S phase transition / urinary bladder smooth muscle contraction / P-type calcium transporter activity / negative regulation of nitric oxide biosynthetic process / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / ATPase-coupled monoatomic cation transmembrane transporter activity / protein phosphatase 2B binding / positive regulation of cAMP-dependent protein kinase activity / CaM pathway / Cam-PDE 1 activation / Sodium/Calcium exchangers / calcium ion transmembrane import into cytosol / regulation of synaptic vesicle endocytosis / negative regulation of cardiac muscle hypertrophy in response to stress / Calmodulin induced events / Reduction of cytosolic Ca++ levels / negative regulation of calcineurin-NFAT signaling cascade / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Activation of Ca-permeable Kainate Receptor / Loss of phosphorylation of MECP2 at T308 / CREB1 phosphorylation through the activation of Adenylate Cyclase / PKA activation / negative regulation of high voltage-gated calcium channel activity / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / CLEC7A (Dectin-1) induces NFAT activation / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / Activation of RAC1 downstream of NMDARs / response to corticosterone / nitric-oxide synthase binding / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / Negative regulation of NMDA receptor-mediated neuronal transmission / negative regulation of peptidyl-threonine phosphorylation / Synthesis of IP3 and IP4 in the cytosol / Unblocking of NMDA receptors, glutamate binding and activation / Phase 0 - rapid depolarisation / protein phosphatase activator activity / plasma membrane => GO:0005886 / RHO GTPases activate PAKs / positive regulation of phosphoprotein phosphatase activity / Ion transport by P-type ATPases / Long-term potentiation / Uptake and function of anthrax toxins / negative regulation of blood vessel endothelial cell migration / Calcineurin activates NFAT / Regulation of MECP2 expression and activity / adenylate cyclase binding / transport across blood-brain barrier / catalytic complex / DARPP-32 events / detection of calcium ion / regulation of cardiac muscle contraction / calcium ion import across plasma membrane / negative regulation of ryanodine-sensitive calcium-release channel activity / regulation of cardiac conduction / Smooth Muscle Contraction / sperm flagellum / sodium channel regulator activity / calcium channel inhibitor activity / RHO GTPases activate IQGAPs / cellular response to interferon-beta / positive regulation of DNA binding / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / Protein methylation / phosphatidylinositol 3-kinase binding / eNOS activation / Activation of AMPK downstream of NMDARs / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / presynaptic active zone membrane / enzyme regulator activity / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 類似検索 - 分子機能 Plasma membrane calcium-transporting ATPase 4 / Plasma membrane calcium transporting P-type ATPase, C-terminal / Plasma membrane calcium transporter ATPase C terminal / P-type ATPase, subfamily IIB / Cation-transporting P-type ATPase, C-terminal / Cation transporting ATPase, C-terminus / Cation transporter/ATPase, N-terminus / Cation-transporting P-type ATPase, N-terminal / Cation transporter/ATPase, N-terminus / Cation transport ATPase (P-type) ... Plasma membrane calcium-transporting ATPase 4 / Plasma membrane calcium transporting P-type ATPase, C-terminal / Plasma membrane calcium transporter ATPase C terminal / P-type ATPase, subfamily IIB / Cation-transporting P-type ATPase, C-terminal / Cation transporting ATPase, C-terminus / Cation transporter/ATPase, N-terminus / Cation-transporting P-type ATPase, N-terminal / Cation transporter/ATPase, N-terminus / Cation transport ATPase (P-type) / E1-E2 ATPase / P-type ATPase, haloacid dehalogenase domain / P-type ATPase, phosphorylation site / P-type ATPase, cytoplasmic domain N / E1-E2 ATPases phosphorylation site. / P-type ATPase, A domain superfamily / P-type ATPase / P-type ATPase, transmembrane domain superfamily / haloacid dehalogenase-like hydrolase / EF-hand / Recoverin; domain 1 / HAD superfamily / HAD-like superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Plasma membrane calcium-transporting ATPase 4 / Calmodulin-1 / Plasma membrane calcium-transporting ATPase 4 / Calmodulin-3 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細Model details lowest energy, model 1 データ登録者 Juranic, N. / Atanasova, E. / Filoteo, A.G. / Macura, S. / Prendergast, F.G. / Penniston, J.T. / Strehler, E.E. 引用ジャーナル : J.Biol.Chem. / 年 : 2010タイトル : Calmodulin wraps around its binding domain in the plasma membrane Ca2+ pump anchored by a novel 18-1 motif.著者 : Juranic, N. / Atanasova, E. / Filoteo, A.G. / Macura, S. / Prendergast, F.G. / Penniston, J.T. / Strehler, E.E. 履歴 登録 2009年8月21日 登録サイト : BMRB / 処理サイト : RCSB改定 1.0 2009年11月24日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2020年2月26日 Group : Data collection / Derived calculations / Otherカテゴリ : pdbx_database_status / pdbx_nmr_software ... pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list Item : _pdbx_database_status.status_code_cs / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model改定 1.3 2023年6月14日 Group : Database references / Derived calculations / Otherカテゴリ : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.4 2024年5月8日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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