interleukin-33 receptor binding / negative regulation of macrophage proliferation / positive regulation of CD86 production / positive regulation of CD80 production / positive regulation of cellular defense response / Interleukin-33 signaling / positive regulation of MHC class I biosynthetic process / negative regulation of T-helper 1 type immune response / negative regulation of immunoglobulin production / microglial cell activation involved in immune response ...interleukin-33 receptor binding / negative regulation of macrophage proliferation / positive regulation of CD86 production / positive regulation of CD80 production / positive regulation of cellular defense response / Interleukin-33 signaling / positive regulation of MHC class I biosynthetic process / negative regulation of T-helper 1 type immune response / negative regulation of immunoglobulin production / microglial cell activation involved in immune response / negative regulation of inflammatory response to wounding / negative regulation of leukocyte migration / microglial cell proliferation / interleukin-33-mediated signaling pathway / positive regulation of type 2 immune response / positive regulation of interleukin-13 production / positive regulation of neuroinflammatory response / positive regulation of interleukin-5 production / type 2 immune response / positive regulation of MHC class II biosynthetic process / positive regulation of macrophage activation / positive regulation of immunoglobulin production / positive regulation of oligodendrocyte differentiation / positive regulation of interleukin-4 production / positive regulation of nitric-oxide synthase biosynthetic process / macrophage differentiation / negative regulation of type II interferon production / positive regulation of chemokine production / extrinsic apoptotic signaling pathway / transport vesicle / positive regulation of cytokine production / cytokine activity / positive regulation of inflammatory response / cellular response to mechanical stimulus / positive regulation of interleukin-6 production / protein import into nucleus / positive regulation of tumor necrosis factor production / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / PIP3 activates AKT signaling / chromosome / gene expression / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / defense response to virus / Ub-specific processing proteases / intracellular membrane-bounded organelle / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / nucleoplasm / nucleus / cytoplasm Similarity search - Function
Method: simulated annealing / Software ordinal: 1 Details: Distance restraints were derived from 15N- or 13C-resolved 3D NOESY experiments and a 2D homonuclear 1H NOESY experiment. Restraints for the backbone angles phi and psi were derived from ...Details: Distance restraints were derived from 15N- or 13C-resolved 3D NOESY experiments and a 2D homonuclear 1H NOESY experiment. Restraints for the backbone angles phi and psi were derived from TALOS. Stereospecific assignments of Leu, Val methyl groups were obtained using a 10% fractionally 13C-labeled sample. For the definition of H-bonds, slowly exchanging amide protons were identified from 1H, 15N correlation experiments after redissolving lyophilized protein in D2O.
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 10
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