登録情報 | データベース: PDB / ID: 2k4a |
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タイトル | FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway |
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要素 | - Heparin-binding growth factor 1
- Synaptotagmin-1
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キーワード | PROTEIN TRANSPORT / beta barrel / FGF1-C2A binary complex / Calcium / Cell junction / Cytoplasmic vesicle / Glycoprotein / Lipoprotein / Membrane / Metal-binding / Palmitate / Phosphoprotein / Synapse / Transmembrane / Acetylation / Angiogenesis / Developmental protein / Differentiation / Growth factor / Heparin-binding / Mitogen / Polymorphism |
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機能・相同性 | 機能・相同性情報
clathrin-sculpted acetylcholine transport vesicle membrane / Toxicity of botulinum toxin type G (botG) / clathrin-sculpted glutamate transport vesicle membrane / synchronous neurotransmitter secretion / fast, calcium ion-dependent exocytosis of neurotransmitter / positive regulation of calcium ion-dependent exocytosis of neurotransmitter / syntaxin-3 binding / calcium-dependent activation of synaptic vesicle fusion / calcium ion sensor activity / regulation of regulated secretory pathway ...clathrin-sculpted acetylcholine transport vesicle membrane / Toxicity of botulinum toxin type G (botG) / clathrin-sculpted glutamate transport vesicle membrane / synchronous neurotransmitter secretion / fast, calcium ion-dependent exocytosis of neurotransmitter / positive regulation of calcium ion-dependent exocytosis of neurotransmitter / syntaxin-3 binding / calcium-dependent activation of synaptic vesicle fusion / calcium ion sensor activity / regulation of regulated secretory pathway / Acetylcholine Neurotransmitter Release Cycle / Toxicity of botulinum toxin type B (botB) / spontaneous neurotransmitter secretion / clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane / clathrin-sculpted monoamine transport vesicle membrane / dense core granule / chromaffin granule membrane / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / mesonephric epithelium development / calcium ion-regulated exocytosis of neurotransmitter / branch elongation involved in ureteric bud branching / regulation of endothelial tube morphogenesis / Dopamine Neurotransmitter Release Cycle / FGFR3b ligand binding and activation / Norepinephrine Neurotransmitter Release Cycle / regulation of calcium ion-dependent exocytosis / vesicle docking / regulation of endothelial cell chemotaxis to fibroblast growth factor / exocytic vesicle / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / positive regulation of dopamine secretion / protein heterooligomerization / Phospholipase C-mediated cascade; FGFR3 / Glutamate Neurotransmitter Release Cycle / FGFR2b ligand binding and activation / positive regulation of cholesterol biosynthetic process / fibroblast growth factor receptor binding / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / Phospholipase C-mediated cascade; FGFR2 / FGFR4 ligand binding and activation / positive regulation of dendrite extension / FGFR1b ligand binding and activation / Phospholipase C-mediated cascade; FGFR4 / regulation of exocytosis / neurotransmitter secretion / Signaling by activated point mutants of FGFR1 / FGFR1c ligand binding and activation / organ induction / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / calcium-dependent phospholipid binding / neuron projection terminus / positive regulation of hepatocyte proliferation / Neurexins and neuroligins / S100 protein binding / syntaxin-1 binding / positive regulation of intracellular signal transduction / syntaxin binding / Signaling by FGFR2 IIIa TM / low-density lipoprotein particle receptor binding / clathrin binding / PI-3K cascade:FGFR3 / regulation of dopamine secretion / PI-3K cascade:FGFR2 / positive regulation of sprouting angiogenesis / PI-3K cascade:FGFR4 / phosphatidylserine binding / PI-3K cascade:FGFR1 / positive regulation of cell division / excitatory synapse / synaptic vesicle endocytosis / detection of calcium ion / PI3K Cascade / fibroblast growth factor receptor signaling pathway / anatomical structure morphogenesis / positive regulation of synaptic transmission / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR3 signaling / FRS-mediated FGFR2 signaling / regulation of synaptic transmission, glutamatergic / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / Signaling by FGFR2 in disease / Hsp70 protein binding / cellular response to calcium ion / phosphatidylinositol-4,5-bisphosphate binding / Signaling by FGFR1 in disease / activation of protein kinase B activity / hippocampal mossy fiber to CA3 synapse / positive regulation of endothelial cell migration / SNARE binding / extracellular matrix / epithelial cell proliferation類似検索 - 分子機能 Synaptotagmin / HBGF/FGF family signature. / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGF / C2 domain / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain ...Synaptotagmin / HBGF/FGF family signature. / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGF / C2 domain / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / C2 domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Fibroblast growth factor 1 / Synaptotagmin-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Yu, C. / Mohan, S.K. |
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引用 | ジャーナル: To be Published タイトル: FGF-1-C2A binary complex structure: key component in the acidic fibroblast growth factor release 著者: Mohan, S.K. / Yu, C. |
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履歴 | 登録 | 2008年6月2日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2009年6月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2022年3月16日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name |
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改定 1.3 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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