Entry Database : PDB / ID : 2jod Structure visualization Downloads & linksTitle Pac1-Rshort N-terminal EC domain Pacap(6-38) complex ComponentsPituitary adenylate cyclase-activating polypeptide Pituitary adenylate cyclase-activating polypeptide type I receptor DetailsKeywords SIGNALING PROTEIN / protein-peptide complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of response to reactive oxygen species / development of primary female sexual characteristics / pituitary adenylate cyclase activating polypeptide activity / vasoactive intestinal polypeptide receptor activity / positive regulation of growth hormone secretion / positive regulation of chemokine (C-C motif) ligand 5 production / positive regulation of cAMP-mediated signaling / NGF-independant TRKA activation / regulation of G protein-coupled receptor signaling pathway / neuropeptide hormone activity ... negative regulation of response to reactive oxygen species / development of primary female sexual characteristics / pituitary adenylate cyclase activating polypeptide activity / vasoactive intestinal polypeptide receptor activity / positive regulation of growth hormone secretion / positive regulation of chemokine (C-C motif) ligand 5 production / positive regulation of cAMP-mediated signaling / NGF-independant TRKA activation / regulation of G protein-coupled receptor signaling pathway / neuropeptide hormone activity / neuropeptide binding / G protein-coupled peptide receptor activity / positive regulation of small GTPase mediated signal transduction / insulin secretion / peptide hormone receptor binding / positive regulation of inositol phosphate biosynthetic process / positive regulation of calcium ion transport into cytosol / peptide hormone binding / adenylate cyclase binding / negative regulation of cell cycle / bicellular tight junction / positive regulation of protein kinase activity / neuropeptide signaling pathway / multicellular organismal response to stress / activation of adenylate cyclase activity / cAMP-mediated signaling / positive regulation of GTPase activity / caveola / female pregnancy / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / small GTPase binding / Glucagon-type ligand receptors / regulation of protein localization / neuron projection development / response to estradiol / cell-cell signaling / signaling receptor activity / positive regulation of cold-induced thermogenesis / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / spermatogenesis / perikaryon / response to ethanol / positive regulation of ERK1 and ERK2 cascade / cell surface receptor signaling pathway / cell differentiation / receptor complex / endosome / response to xenobiotic stimulus / neuron projection / intracellular membrane-bounded organelle / signaling receptor binding / cell surface / positive regulation of transcription by RNA polymerase II / extracellular region / plasma membrane Similarity search - Function GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor / : / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain ... GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor / : / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Few Secondary Structures / Irregular Similarity search - Domain/homology Pituitary adenylate cyclase-activating polypeptide / Pituitary adenylate cyclase-activating polypeptide type I receptor Similarity search - ComponentBiological species Homo sapiens (human)Method SOLUTION NMR / simulated annealing DetailsModel type details minimized average Authors Olejniczak, E.T. / Sun, C. / Song, D. / Davis-Taber, R.A. / Barrett, L.W. / Scott, V.E. / Richardson, P.L. / Pereda-lopez, A. / Uchic, M.E. / Solomon, L.R. ...Olejniczak, E.T. / Sun, C. / Song, D. / Davis-Taber, R.A. / Barrett, L.W. / Scott, V.E. / Richardson, P.L. / Pereda-lopez, A. / Uchic, M.E. / Solomon, L.R. / Lake, M.R. / Walter, K.A. / Hajduk, P.J. CitationJournal : Proc.Natl.Acad.Sci.Usa / Year : 2007Title : Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.Authors : Sun, C. / Song, D. / Davis-Taber, R.A. / Barrett, L.W. / Scott, V.E. / Richardson, P.L. / Pereda-Lopez, A. / Uchic, M.E. / Solomon, L.R. / Lake, M.R. / Walter, K.A. / Hajduk, P.J. / Olejniczak, E.T. History Deposition Mar 7, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 22, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Feb 5, 2020 Group : Database references / Derived calculations ... Database references / Derived calculations / Experimental preparation / Other Category : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_sample_details / pdbx_struct_assembly / pdbx_struct_assembly_prop / pdbx_struct_oper_list / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _pdbx_nmr_sample_details.contents / _struct_ref_seq_dif.detailsRevision 1.4 Oct 20, 2021 Group : Database references / Category : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.detailsRevision 1.5 Dec 20, 2023 Group : Data collection / OtherCategory : chem_comp_atom / chem_comp_bond / pdbx_database_statusItem : _pdbx_database_status.deposit_site
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