Entry | Database: PDB / ID: 2jii |
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Title | Structure of vaccinia related kinase 3 |
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Components | SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3 |
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Keywords | TRANSFERASE / PSEUDO KINASE DOMAIN / VACCINIA RELATED KINASE / SERINE/THREONINE-PROTEIN KINASE / VRK3 / KINASE / ATP-BINDING / NUCLEOTIDE-BINDING |
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Function / homology | Function and homology information
ERKs are inactivated / positive regulation of phosphoprotein phosphatase activity / negative regulation of ERK1 and ERK2 cascade / peptidyl-serine phosphorylation / protein phosphatase binding / intracellular membrane-bounded organelle / protein serine/threonine kinase activity / nucleolus / nucleoplasm / ATP binding ...ERKs are inactivated / positive regulation of phosphoprotein phosphatase activity / negative regulation of ERK1 and ERK2 cascade / peptidyl-serine phosphorylation / protein phosphatase binding / intracellular membrane-bounded organelle / protein serine/threonine kinase activity / nucleolus / nucleoplasm / ATP binding / nucleus / cytoplasmSimilarity search - Function Zinc-ribbon domain / zinc-ribbon domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain ...Zinc-ribbon domain / zinc-ribbon domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Bunkoczi, G. / Eswaran, J. / Pike, A.C.W. / Uppenberg, J. / Ugochukwu, E. / von Delft, F. / Cooper, C. / Salah, E. / Savitsky, P. / Burgess-Brown, N. ...Bunkoczi, G. / Eswaran, J. / Pike, A.C.W. / Uppenberg, J. / Ugochukwu, E. / von Delft, F. / Cooper, C. / Salah, E. / Savitsky, P. / Burgess-Brown, N. / Keates, T. / Fedorov, O. / Sobott, F. / Arrowsmith, C.H. / Edwards, A. / Sundstrom, M. / Weigelt, J. / Knapp, S. |
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Citation | Journal: Structure / Year: 2009 Title: Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Authors: Scheeff, E.D. / Eswaran, J. / Bunkoczi, G. / Knapp, S. / Manning, G. |
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History | Deposition | Jun 28, 2007 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 10, 2007 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Feb 28, 2018 | Group: Database references / Source and taxonomy / Category: citation / entity_src_gen Item: _citation.page_last / _citation.pdbx_database_id_DOI ..._citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_gen.pdbx_host_org_variant |
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Revision 1.3 | May 1, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_ncs_dom_lim / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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