Entry | Database: PDB / ID: 2jar |
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Title | Crystal structure of D12N variant of mouse cytosolic 5'(3')- deoxyribonucleotidase (cdN) in complex with deoxyuridine 5'- monophosphate |
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Components | 5'(3')-DEOXYRIBONUCLEOTIDASE |
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Keywords | HYDROLASE / NUCLEOTIDE METABOLISM / NUCLEOTIDE-BINDING / ALFA BETA FOLD / METAL- BINDING / TRANSIT PEPTIDE / CYTOSOLIC / MAGNESIUM / METAL-BINDING |
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Function / homology | Function and homology information
Purine catabolism / pyrimidine nucleotide binding / Pyrimidine catabolism / dTMP catabolic process / UMP catabolic process / pyrimidine deoxyribonucleotide catabolic process / dCMP catabolic process / dGMP catabolic process / dUMP catabolic process / amide catabolic process ...Purine catabolism / pyrimidine nucleotide binding / Pyrimidine catabolism / dTMP catabolic process / UMP catabolic process / pyrimidine deoxyribonucleotide catabolic process / dCMP catabolic process / dGMP catabolic process / dUMP catabolic process / amide catabolic process / IMP 5'-nucleotidase activity / IMP catabolic process / deoxyribonucleotide catabolic process / allantoin metabolic process / Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases / 5'-nucleotidase activity / dephosphorylation / phosphatase activity / mitochondrion / identical protein binding / nucleus / metal ion binding / cytosolSimilarity search - Function 5'(3')-deoxyribonucleotidase / 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) / Deoxyribonucleotidase; domain 2 / Ribonucleotide Reductase Protein R1; domain 1 / HAD superfamily/HAD-like / HAD superfamily / HAD-like superfamily / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich ...5'(3')-deoxyribonucleotidase / 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) / Deoxyribonucleotidase; domain 2 / Ribonucleotide Reductase Protein R1; domain 1 / HAD superfamily/HAD-like / HAD superfamily / HAD-like superfamily / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | MUS MUSCULUS (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.94 Å |
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Authors | Wallden, K. / Ruzzenente, B. / Bianchi, V. / Nordlund, P. |
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Citation | Journal: Biochemistry / Year: 2007 Title: Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues. Authors: Wallden, K. / Rinaldo-Matthis, A. / Ruzzenente, B. / Rampazzo, C. / Bianchi, V. / Nordlund, P. |
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History | Deposition | Nov 30, 2006 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 20, 2007 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 8, 2011 | Group: Version format compliance |
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Revision 1.2 | Jul 13, 2011 | Group: Version format compliance |
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Revision 1.3 | May 15, 2019 | Group: Data collection / Experimental preparation / Other Category: exptl_crystal_grow / pdbx_database_proc ...exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol Item: _exptl_crystal_grow.method / _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval |
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Revision 1.4 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id |
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