登録情報 | データベース: PDB / ID: 2i4q |
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タイトル | Human renin/PF02342674 complex |
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要素 | Renin |
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キーワード | HYDROLASE / RENIN INHIBITOR / PROTEIN-LIGAND COMPLEX |
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機能・相同性 | 機能・相同性情報
renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process / Metabolism of Angiotensinogen to Angiotensins / cell maturation / response to cAMP / hormone-mediated signaling pathway / kidney development / insulin-like growth factor receptor binding / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Holsworth, D.D. / Jalaie, M. / Zhang, E. / Mcconnell, P. / Mochalkin, I. / Finzel, B.C. |
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引用 | ジャーナル: Bioorg.Med.Chem. / 年: 2007 タイトル: Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. 著者: Powell, N.A. / Ciske, F.L. / Cai, C. / Holsworth, D.D. / Mennen, K. / Van Huis, C.A. / Jalaie, M. / Day, J. / Mastronardi, M. / McConnell, P. / Mochalkin, I. / Zhang, E. / Ryan, M.J. / ...著者: Powell, N.A. / Ciske, F.L. / Cai, C. / Holsworth, D.D. / Mennen, K. / Van Huis, C.A. / Jalaie, M. / Day, J. / Mastronardi, M. / McConnell, P. / Mochalkin, I. / Zhang, E. / Ryan, M.J. / Bryant, J. / Collard, W. / Ferreira, S. / Gu, C. / Collins, R. / Edmunds, J.J. |
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履歴 | 登録 | 2006年8月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年10月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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