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Open data
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Basic information
Entry | Database: PDB / ID: 2hu0 | ||||||
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Title | N1 neuraminidase in complex with oseltamivir 1 | ||||||
![]() | Neuraminidase | ||||||
![]() | HYDROLASE / N1 / neuraminidase / oseltamivir | ||||||
Function / homology | ![]() exo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activity / exo-alpha-sialidase / viral budding from plasma membrane / carbohydrate metabolic process / host cell plasma membrane / virion membrane / identical protein binding / membrane / metal ion binding Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Russell, R.J. / Haire, L.F. / Stevens, D.J. / Collins, P.J. / Lin, Y.P. / Blackburn, G.M. / Hay, A.J. / Gamblin, S.J. / Skehel, J.J. | ||||||
![]() | ![]() Title: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Authors: Russell, R.J. / Haire, L.F. / Stevens, D.J. / Collins, P.J. / Lin, Y.P. / Blackburn, G.M. / Hay, A.J. / Gamblin, S.J. / Skehel, J.J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 568.3 KB | Display | ![]() |
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PDB format | ![]() | 483.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 758.9 KB | Display | ![]() |
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Full document | ![]() | 892.9 KB | Display | |
Data in XML | ![]() | 79.5 KB | Display | |
Data in CIF | ![]() | 116.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2ht5C ![]() 2ht7C ![]() 2ht8C ![]() 2htqC ![]() 2htrC ![]() 2htuC ![]() 2htvC ![]() 2htwC ![]() 2htyC ![]() 2hu4C C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 42429.180 Da / Num. of mol.: 8 / Mutation: H253Y / Source method: isolated from a natural source / Source: (natural) ![]() ![]() #2: Chemical | ChemComp-G39 / ( | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.29 Å3/Da / Density % sol: 62.58 % |
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Crystal grow | Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 8 Details: MES, PEG3350, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() |
Detector | Type: RIGAKU RAXIS IV / Detector: IMAGE PLATE / Date: Mar 3, 2006 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.54 Å / Relative weight: 1 |
Reflection | Resolution: 2.95→30 Å / Num. all: 88347 / Num. obs: 70678 / % possible obs: 79.4 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 |
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Processing
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Refinement | Method to determine structure: ![]()
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Solvent computation | Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.95→142.86 Å
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Refine LS restraints |
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LS refinement shell | Highest resolution: 2.95 Å / Num. reflection Rwork: 4782 / Total num. of bins used: 20 |