+Open data
-Basic information
Entry | Database: PDB / ID: 2hty | |||||||||
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Title | N1 neuraminidase | |||||||||
Components | Neuraminidase | |||||||||
Keywords | HYDROLASE / N1 / neuraminidase | |||||||||
Function / homology | Function and homology information exo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activity / exo-alpha-sialidase / viral budding from plasma membrane / carbohydrate metabolic process / host cell plasma membrane / virion membrane / identical protein binding / membrane / metal ion binding Similarity search - Function | |||||||||
Biological species | Influenza A virus | |||||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.5 Å | |||||||||
Authors | Russell, R.J. / Haire, L.F. / Stevens, D.J. / Collins, P.J. / Lin, Y.P. / Blackburn, G.M. / Hay, A.J. / Gamblin, S.J. / Skehel, J.J. | |||||||||
Citation | Journal: Nature / Year: 2006 Title: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Authors: Russell, R.J. / Haire, L.F. / Stevens, D.J. / Collins, P.J. / Lin, Y.P. / Blackburn, G.M. / Hay, A.J. / Gamblin, S.J. / Skehel, J.J. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2hty.cif.gz | 590.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2hty.ent.gz | 499.5 KB | Display | PDB format |
PDBx/mmJSON format | 2hty.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2hty_validation.pdf.gz | 561.3 KB | Display | wwPDB validaton report |
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Full document | 2hty_full_validation.pdf.gz | 701.3 KB | Display | |
Data in XML | 2hty_validation.xml.gz | 130.4 KB | Display | |
Data in CIF | 2hty_validation.cif.gz | 176.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ht/2hty ftp://data.pdbj.org/pub/pdb/validation_reports/ht/2hty | HTTPS FTP |
-Related structure data
Related structure data | 2ht5C 2ht7C 2ht8C 2htqC 2htrC 2htuC 2htvC 2htwC 2hu0C 2hu4C C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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1 |
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2 |
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Unit cell |
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-Components
#1: Protein | Mass: 42429.180 Da / Num. of mol.: 8 / Mutation: H253Y / Source method: isolated from a natural source / Source: (natural) Influenza A virus / Genus: Influenzavirus A / References: UniProt: Q6DPL2 #2: Sugar | ChemComp-NDG / #3: Chemical | ChemComp-CA / #4: Sugar | ChemComp-NAG / | #5: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION / Number of used crystals: 1 |
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-Sample preparation
Crystal | Density Matthews: 3.13 Å3/Da / Density % sol: 60.73 % |
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-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ROTATING ANODE / Type: RIGAKU / Wavelength: 1.54 Å |
Detector | Type: RIGAKU RAXIS IV / Detector: IMAGE PLATE / Date: Mar 3, 2006 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.54 Å / Relative weight: 1 |
Reflection | Resolution: 2.5→30 Å / Num. all: 146515 / Num. obs: 143352 / % possible obs: 98 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 / Rsym value: 0.119 / Net I/σ(I): 7.1 |
-Processing
Software |
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Refinement | Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.5→30 Å / Cross valid method: THROUGHOUT / σ(F): 0 / Stereochemistry target values: Engh & Huber
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Refinement step | Cycle: LAST / Resolution: 2.5→30 Å
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