- PDB-2hqw: Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1... -
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Basic information
Entry
Database: PDB / ID: 2hqw
Title
Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1 peptide
Components
Calmodulin
Glutamate NMDA receptor subunit zeta 1
Keywords
METAL BINDING PROTEIN / Calmodulin / EF hand motif / globular complex / ion channel / NR1 / C1 casette / N-methyl-D-aspartate receptor / glutamate / central nervous system / neuronal channel / calcium channel / ER retention signal
Function / homology
Function and homology information
regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / excitatory chemical synaptic transmission / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / pons maturation / Synaptic adhesion-like molecules / regulation of cell communication ...regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / excitatory chemical synaptic transmission / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / pons maturation / Synaptic adhesion-like molecules / regulation of cell communication / positive regulation of Schwann cell migration / : / EPHB-mediated forward signaling / Assembly and cell surface presentation of NMDA receptors / olfactory learning / establishment of protein localization to mitochondrial membrane / conditioned taste aversion / protein localization to postsynaptic membrane / dendritic branch / regulation of respiratory gaseous exchange / propylene metabolic process / response to glycine / type 3 metabotropic glutamate receptor binding / voltage-gated monoatomic cation channel activity / response to morphine / glutamate-gated calcium ion channel activity / Assembly and cell surface presentation of NMDA receptors / regulation of monoatomic cation transmembrane transport / establishment of protein localization to membrane / Neurexins and neuroligins / NMDA glutamate receptor activity / NMDA selective glutamate receptor complex / RAF/MAP kinase cascade / Synaptic adhesion-like molecules / parallel fiber to Purkinje cell synapse / calcium ion transmembrane import into cytosol / protein heterotetramerization / glutamate binding / positive regulation of reactive oxygen species biosynthetic process / neuromuscular process / regulation of synaptic vesicle endocytosis / regulation of synapse assembly / negative regulation of high voltage-gated calcium channel activity / glycine binding / regulation of synaptic vesicle exocytosis / positive regulation of calcium ion transport into cytosol / negative regulation of calcium ion export across plasma membrane / organelle localization by membrane tethering / male mating behavior / regulation of neuronal synaptic plasticity / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / regulation of dendrite morphogenesis / autophagosome membrane docking / regulation of axonogenesis / suckling behavior / positive regulation of ryanodine-sensitive calcium-release channel activity / Negative regulation of NMDA receptor-mediated neuronal transmission / nitric-oxide synthase binding / startle response / Unblocking of NMDA receptors, glutamate binding and activation / response to amine / protein phosphatase activator activity / monoatomic cation transmembrane transport / social behavior / positive regulation of excitatory postsynaptic potential / calcium channel regulator activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / ligand-gated monoatomic ion channel activity / associative learning / positive regulation of phosphoprotein phosphatase activity / Long-term potentiation / monoatomic cation transport / excitatory synapse / positive regulation of dendritic spine maintenance / adenylate cyclase binding / catalytic complex / detection of calcium ion / negative regulation of ryanodine-sensitive calcium-release channel activity / Unblocking of NMDA receptors, glutamate binding and activation / long-term memory / glutamate receptor binding / cellular response to interferon-beta / regulation of cardiac muscle contraction / phosphatase binding / calcium channel inhibitor activity / calcium ion homeostasis / positive regulation of DNA binding / synaptic cleft / cellular response to manganese ion / enzyme regulator activity / prepulse inhibition / voltage-gated potassium channel complex / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of neuron apoptotic process / presynaptic active zone membrane / glutamate-gated receptor activity / response to fungicide / monoatomic cation channel activity Similarity search - Function
EF-hand / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Recoverin; domain 1 ...EF-hand / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Recoverin; domain 1 / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / EF-hand domain pair / Periplasmic binding protein-like I / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Mass: 2765.287 Da / Num. of mol.: 1 / Fragment: C-TERMINAL TAIL, C1 REGION / Source method: obtained synthetically Details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in Homo sapiens (human). References: UniProt: Q05586, UniProt: P35439*PLUS
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