- PDB-2hqw: Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1... -
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Basic information
Entry
Database: PDB / ID: 2hqw
Title
Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1 peptide
Components
Calmodulin
Glutamate NMDA receptor subunit zeta 1
Keywords
METAL BINDING PROTEIN / Calmodulin / EF hand motif / globular complex / ion channel / NR1 / C1 casette / N-methyl-D-aspartate receptor / glutamate / central nervous system / neuronal channel / calcium channel / ER retention signal
Function / homology
Function and homology information
regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / excitatory chemical synaptic transmission / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / pons maturation / regulation of cell communication / positive regulation of Schwann cell migration ...regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / excitatory chemical synaptic transmission / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / pons maturation / regulation of cell communication / positive regulation of Schwann cell migration / Synaptic adhesion-like molecules / : / EPHB-mediated forward signaling / Assembly and cell surface presentation of NMDA receptors / olfactory learning / establishment of protein localization to mitochondrial membrane / conditioned taste aversion / dendritic branch / regulation of respiratory gaseous exchange / protein localization to postsynaptic membrane / type 3 metabotropic glutamate receptor binding / propylene metabolic process / response to glycine / voltage-gated monoatomic cation channel activity / establishment of protein localization to membrane / regulation of monoatomic cation transmembrane transport / response to morphine / NMDA glutamate receptor activity / Assembly and cell surface presentation of NMDA receptors / Neurexins and neuroligins / Synaptic adhesion-like molecules / NMDA selective glutamate receptor complex / glutamate-gated calcium ion channel activity / RAF/MAP kinase cascade / parallel fiber to Purkinje cell synapse / calcium ion transmembrane import into cytosol / regulation of synaptic vesicle endocytosis / protein heterotetramerization / glutamate binding / neuromuscular process / positive regulation of reactive oxygen species biosynthetic process / regulation of synapse assembly / negative regulation of high voltage-gated calcium channel activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / glycine binding / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / positive regulation of calcium ion transport into cytosol / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / regulation of dendrite morphogenesis / regulation of axonogenesis / male mating behavior / nitric-oxide synthase binding / suckling behavior / positive regulation of ryanodine-sensitive calcium-release channel activity / Negative regulation of NMDA receptor-mediated neuronal transmission / startle response / Unblocking of NMDA receptors, glutamate binding and activation / response to amine / monoatomic cation transmembrane transport / monoatomic cation transport / regulation of neuronal synaptic plasticity / protein phosphatase activator activity / associative learning / positive regulation of excitatory postsynaptic potential / positive regulation of phosphoprotein phosphatase activity / social behavior / ligand-gated monoatomic ion channel activity / Long-term potentiation / adenylate cyclase binding / cellular response to glycine / excitatory synapse / catalytic complex / calcium channel regulator activity / positive regulation of dendritic spine maintenance / detection of calcium ion / regulation of cardiac muscle contraction / negative regulation of ryanodine-sensitive calcium-release channel activity / Unblocking of NMDA receptors, glutamate binding and activation / phosphatase binding / calcium channel inhibitor activity / cellular response to interferon-beta / cellular response to manganese ion / positive regulation of DNA binding / calcium ion homeostasis / glutamate receptor binding / prepulse inhibition / monoatomic cation channel activity / long-term memory / phosphatidylinositol 3-kinase binding / regulation of neuron apoptotic process / synaptic cleft / glutamate-gated receptor activity / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / presynaptic active zone membrane / enzyme regulator activity / response to fungicide Similarity search - Function
: / : / EF-hand / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Recoverin; domain 1 / Ligand-gated ion channel ...: / : / EF-hand / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Recoverin; domain 1 / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / EF-hand domain pair / Periplasmic binding protein-like I / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Mass: 2765.287 Da / Num. of mol.: 1 / Fragment: C-TERMINAL TAIL, C1 REGION / Source method: obtained synthetically Details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in Homo sapiens (human). References: UniProt: Q05586, UniProt: P35439*PLUS
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