登録情報 データベース : PDB / ID : 2hfp 構造の表示 ダウンロードとリンクタイトル Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands 要素Peroxisome proliferator-activated receptor gamma SRC Peptide Fragment 詳細キーワード TRANSCRIPTION / PPAR PPARGamma LBD機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of receptor signaling pathway via STAT / prostaglandin receptor activity / regulation of cholesterol transporter activity / MECP2 regulates transcription factors / negative regulation of extracellular matrix assembly / negative regulation of vascular endothelial cell proliferation / negative regulation of cellular response to transforming growth factor beta stimulus / negative regulation of cardiac muscle hypertrophy in response to stress / positive regulation of low-density lipoprotein receptor activity ... negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of receptor signaling pathway via STAT / prostaglandin receptor activity / regulation of cholesterol transporter activity / MECP2 regulates transcription factors / negative regulation of extracellular matrix assembly / negative regulation of vascular endothelial cell proliferation / negative regulation of cellular response to transforming growth factor beta stimulus / negative regulation of cardiac muscle hypertrophy in response to stress / positive regulation of low-density lipoprotein receptor activity / arachidonate binding / positive regulation of adiponectin secretion / lipoprotein transport / negative regulation of sequestering of triglyceride / macrophage derived foam cell differentiation / DNA binding domain binding / STAT family protein binding / positive regulation of vascular associated smooth muscle cell apoptotic process / positive regulation of fatty acid metabolic process / response to lipid / negative regulation of SMAD protein signal transduction / negative regulation of type II interferon-mediated signaling pathway / LBD domain binding / negative regulation of cholesterol storage / E-box binding / alpha-actinin binding / lipid homeostasis / R-SMAD binding / negative regulation of vascular associated smooth muscle cell proliferation / labyrinthine layer morphogenesis / monocyte differentiation / regulation of thyroid hormone receptor signaling pathway / positive regulation of transcription from RNA polymerase II promoter by galactose / negative regulation of macrophage derived foam cell differentiation / negative regulation of blood vessel endothelial cell migration / positive regulation of female receptivity / negative regulation of lipid storage / cellular response to low-density lipoprotein particle stimulus / white fat cell differentiation / negative regulation of BMP signaling pathway / negative regulation of mitochondrial fission / positive regulation of cholesterol efflux / hypothalamus development / positive regulation of fat cell differentiation / negative regulation of osteoblast differentiation / male mating behavior / retinoic acid receptor signaling pathway / cell fate commitment / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / BMP signaling pathway / long-chain fatty acid transport / nuclear retinoid X receptor binding / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / cell maturation / negative regulation of signaling receptor activity / cellular response to Thyroglobulin triiodothyronine / estrous cycle / epithelial cell differentiation / Synthesis of bile acids and bile salts / Complex I biogenesis / positive regulation of adipose tissue development / hormone-mediated signaling pathway / peroxisome proliferator activated receptor signaling pathway / Endogenous sterols / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Respiratory electron transport / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / negative regulation of angiogenesis / regulation of cellular response to insulin stimulus / response to nutrient / response to retinoic acid / mitochondrial ATP synthesis coupled electron transport / histone acetyltransferase activity / Recycling of bile acids and salts / negative regulation of miRNA transcription / histone acetyltransferase / negative regulation of MAP kinase activity / cellular response to hormone stimulus / mitochondrial respiratory chain complex I assembly / fatty acid metabolic process / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / Regulation of PTEN gene transcription / RORA activates gene expression / transcription coregulator binding / positive regulation of neuron differentiation / lactation / Regulation of lipid metabolism by PPARalpha / cerebellum development / BMAL1:CLOCK,NPAS2 activates circadian gene expression / negative regulation of smooth muscle cell proliferation / SUMOylation of transcription cofactors / Activation of gene expression by SREBF (SREBP) / negative regulation of transforming growth factor beta receptor signaling pathway / positive regulation of miRNA transcription / nuclear receptor coactivator activity / peptide binding / : / mitochondrial electron transport, NADH to ubiquinone / SUMOylation of intracellular receptors / proton motive force-driven mitochondrial ATP synthesis 類似検索 - 分子機能 Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / Nuclear receptor coactivator 1 / : / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 ... Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / Nuclear receptor coactivator 1 / : / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator / DUF1518 / Nuclear receptor coactivator, receptor-binding domain / Nuclear receptor coactivator / Steroid receptor coactivator / Unstructured region on nuclear receptor coactivator protein / NADH dehydrogenase 1, beta subcomplex, subunit 6 / NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit / PAS domain / Nuclear receptor coactivator, interlocking / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / Retinoid X Receptor / Retinoid X Receptor / PAS domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-NSI / NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 / Nuclear receptor coactivator 1 / Nuclear receptor coactivator 1 / Peroxisome proliferator-activated receptor gamma 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Pokross, M.E. / Evdokimov, A.G. / Walter, R.L. / Mekel, M.J. / Hopkins, C.R. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2006タイトル : Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.著者: Hopkins, C.R. / O'neil, S.V. / Laufersweiler, M.C. / Wang, Y. / Pokross, M. / Mekel, M. / Evdokimov, A. / Walter, R. / Kontoyianni, M. / Petrey, M.E. / Sabatakos, G. / Roesgen, J.T. / ... 著者 : Hopkins, C.R. / O'neil, S.V. / Laufersweiler, M.C. / Wang, Y. / Pokross, M. / Mekel, M. / Evdokimov, A. / Walter, R. / Kontoyianni, M. / Petrey, M.E. / Sabatakos, G. / Roesgen, J.T. / Richardson, E. / Demuth Jr., T.P. 履歴 登録 2006年6月25日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2006年9月19日 Provider : repository / タイプ : Initial release改定 1.1 2008年5月1日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2024年2月14日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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