- PDB-2h8p: Structure of a K channel with an amide to ester substitution in t... -
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Basic information
Entry
Database: PDB / ID: 2h8p
Title
Structure of a K channel with an amide to ester substitution in the selectivity filter
Components
FAB heavy chainFragment antigen-binding
FAB light chainFragment antigen-binding
KcsA Channel
Keywords
MEMBRANE PROTEIN / Channel / Semi-synthetic / Ester
Function / homology
Function and homology information
IgG immunoglobulin complex / monoatomic ion transmembrane transport / B cell differentiation / extracellular region / identical protein binding / plasma membrane Similarity search - Function
Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Helix Hairpins - #70 / Potassium channel domain / Ion channel / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Helix Hairpins / Immunoglobulin subtype ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Helix Hairpins - #70 / Potassium channel domain / Ion channel / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Helix Hairpins / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homology
COMPOUND CHAINS C AND D ARE LINKED AND FORM A CONTINUOUS SYNTHETIC POLYPEPTIDE. THERE IS AN ESTER ...COMPOUND CHAINS C AND D ARE LINKED AND FORM A CONTINUOUS SYNTHETIC POLYPEPTIDE. THERE IS AN ESTER BOND BETWEEN RESIDUES TYR 78 AND GOA 79 OF CHAIN C.
Remark 999
SEQUENCE AT THE TIME OF PROCESSING, THERE WERE NO UNP REFERENCE SEQUENCES AVAILABLE FOR THE PROTEINS.
Mass: 10782.549 Da / Num. of mol.: 1 / Source method: obtained synthetically Details: The peptide was synthesized by the expressed protein ligation reaction between a recombinant peptide thioester and a synthetic peptide consisting of a N-terminal cysteine. Source: (synth.) synthetic construct (others) / References: UniProt: P0A334*PLUS
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Antibody , 2 types, 2 molecules AB
#1: Antibody
FABheavychain / Fragment antigen-binding
Mass: 23411.242 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli (E. coli) / References: UniProt: Q569B4*PLUS
#2: Antibody
FABlightchain / Fragment antigen-binding
Mass: 23435.738 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli (E. coli) / References: UniProt: P01837*PLUS
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