登録情報 | データベース: PDB / ID: 2h5l |
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タイトル | S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine |
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要素 | Adenosylhomocysteinase |
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キーワード | HYDROLASE / S-Adenosylhomocysteine / Inhibitor / Hypocholesterolemic activity |
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機能・相同性 | 機能・相同性情報
adenosylselenohomocysteinase activity / S-adenosylhomocysteine catabolic process / Sulfur amino acid metabolism / adenyl nucleotide binding / circadian sleep/wake cycle / chronic inflammatory response to antigenic stimulus / adenosylhomocysteinase / adenosylhomocysteinase activity / Methylation / S-adenosylmethionine cycle ...adenosylselenohomocysteinase activity / S-adenosylhomocysteine catabolic process / Sulfur amino acid metabolism / adenyl nucleotide binding / circadian sleep/wake cycle / chronic inflammatory response to antigenic stimulus / adenosylhomocysteinase / adenosylhomocysteinase activity / Methylation / S-adenosylmethionine cycle / response to nutrient / NAD binding / melanosome / one-carbon metabolic process / response to hypoxia / copper ion binding / endoplasmic reticulum / identical protein binding / nucleus / cytosol類似検索 - 分子機能 Adenosylhomocysteinase-like / Adenosylhomocysteinase-like / S-adenosyl-L-homocysteine hydrolase, conserved site / Adenosylhomocysteinase-like superfamily / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase signature 1. / S-adenosyl-L-homocysteine hydrolase signature 2. / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase, NAD binding domain ...Adenosylhomocysteinase-like / Adenosylhomocysteinase-like / S-adenosyl-L-homocysteine hydrolase, conserved site / Adenosylhomocysteinase-like superfamily / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase signature 1. / S-adenosyl-L-homocysteine hydrolase signature 2. / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-3DD / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / Adenosylhomocysteinase類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Yamada, T. / Komoto, J. / Takusagawa, F. |
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引用 | ジャーナル: Biochem.Pharm. / 年: 2007 タイトル: Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. 著者: Yamada, T. / Komoto, J. / Lou, K. / Ueki, A. / Hua, D.H. / Sugiyama, K. / Takata, Y. / Ogawa, H. / Takusagawa, F. |
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履歴 | 登録 | 2006年5月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年4月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2017年10月18日 | Group: Refinement description / カテゴリ: software |
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改定 1.4 | 2024年2月14日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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