登録情報 | データベース: PDB / ID: 2gbg |
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タイトル | rat DPP-IV with alkynyl cyanopyrrolidine #2 |
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要素 | Dipeptidyl peptidase 4 |
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キーワード | HYDROLASE / serine peptidase beta propeller |
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機能・相同性 | 機能・相同性情報
B-1a B cell differentiation / regulation of T cell mediated immunity / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / positive regulation of natural killer cell mediated immunity / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV ...B-1a B cell differentiation / regulation of T cell mediated immunity / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / positive regulation of natural killer cell mediated immunity / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV / intercellular canaliculus / chemorepellent activity / dipeptidyl-peptidase activity / locomotory exploration behavior / lamellipodium membrane / endocytic vesicle / endothelial cell migration / behavioral fear response / aminopeptidase activity / collagen binding / T cell costimulation / T cell activation / serine-type peptidase activity / peptide binding / protein catabolic process / virus receptor activity / lamellipodium / protease binding / response to hypoxia / cell adhesion / apical plasma membrane / membrane raft / serine-type endopeptidase activity / signaling receptor binding / positive regulation of cell population proliferation / cell surface / protein homodimerization activity / proteolysis / extracellular region / identical protein binding / plasma membrane類似検索 - 分子機能 Dipeptidyl peptidase 4, low complexity region / Dipeptidyl peptidase IV (DPP IV) low complexity region / Dipeptidylpeptidase IV, N-terminal domain / : / 8 Propeller / Methanol Dehydrogenase; Chain A / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region ...Dipeptidyl peptidase 4, low complexity region / Dipeptidyl peptidase IV (DPP IV) low complexity region / Dipeptidylpeptidase IV, N-terminal domain / : / 8 Propeller / Methanol Dehydrogenase; Chain A / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region / Peptidase S9, prolyl oligopeptidase, catalytic domain / Prolyl oligopeptidase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3 Å |
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データ登録者 | Longenecker, K.L. / Jakob, C.G. / Fry, E.H. / Wilk, S. |
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引用 | ジャーナル: Biochemistry / 年: 2006 タイトル: Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors. 著者: Longenecker, K.L. / Stewart, K.D. / Madar, D.J. / Jakob, C.G. / Fry, E.H. / Wilk, S. / Lin, C.W. / Ballaron, S.J. / Stashko, M.A. / Lubben, T.H. / Yong, H. / Pireh, D. / Pei, Z. / Basha, F. / ...著者: Longenecker, K.L. / Stewart, K.D. / Madar, D.J. / Jakob, C.G. / Fry, E.H. / Wilk, S. / Lin, C.W. / Ballaron, S.J. / Stashko, M.A. / Lubben, T.H. / Yong, H. / Pireh, D. / Pei, Z. / Basha, F. / Wiedeman, P.E. / Von Geldern, T.W. / Trevillyan, J.M. / Stoll, V.S. |
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履歴 | 登録 | 2006年3月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年7月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2017年10月18日 | Group: Refinement description / カテゴリ: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version |
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