+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 2g31 | ||||||
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タイトル | Human Nogo-A functional domain: nogo60 | ||||||
要素 | Reticulon-4 | ||||||
キーワード | SIGNALING PROTEIN / NOGO / HELIX | ||||||
機能・相同性 | 機能・相同性情報 cell adhesion involved in sprouting angiogenesis / positive regulation of ERBB3 signaling pathway / endoplasmic reticulum tubular network formation / endoplasmic reticulum tubular network organization / cerebral cortex radial glia-guided migration / positive regulation of neutrophil migration / endoplasmic reticulum tubular network membrane organization / endoplasmic reticulum tubular network membrane / negative regulation of vasculogenesis / positive regulation of artery morphogenesis ...cell adhesion involved in sprouting angiogenesis / positive regulation of ERBB3 signaling pathway / endoplasmic reticulum tubular network formation / endoplasmic reticulum tubular network organization / cerebral cortex radial glia-guided migration / positive regulation of neutrophil migration / endoplasmic reticulum tubular network membrane organization / endoplasmic reticulum tubular network membrane / negative regulation of vasculogenesis / positive regulation of artery morphogenesis / positive regulation of macrophage migration / cell migration involved in vasculogenesis / positive regulation of protein localization to endoplasmic reticulum / intracellular sphingolipid homeostasis / endoplasmic reticulum tubular network / regulation of branching morphogenesis of a nerve / central nervous system vasculogenesis / positive regulation of toll-like receptor 9 signaling pathway / positive regulation of mammary gland epithelial cell proliferation / nuclear pore complex assembly / protein localization to lysosome / cardiac epithelial to mesenchymal transition / negative regulation of axon extension / leukocyte migration involved in inflammatory response / Axonal growth inhibition (RHOA activation) / blastocyst formation / endoplasmic reticulum organization / axonal fasciculation / positive regulation of hepatocyte proliferation / anchoring junction / positive regulation of macrophage cytokine production / positive regulation of epithelial cell migration / positive regulation of Rac protein signal transduction / negative regulation of amyloid-beta formation / regulation of cell migration / modulation of chemical synaptic transmission / neuron differentiation / brain development / negative regulation of cell growth / positive regulation of angiogenesis / cell junction / nuclear envelope / cellular response to hypoxia / regulation of apoptotic process / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / postsynaptic density / protein stabilization / cadherin binding / neuron projection / glutamatergic synapse / apoptotic process / synapse / ubiquitin protein ligase binding / endoplasmic reticulum membrane / endoplasmic reticulum / protein homodimerization activity / RNA binding / metal ion binding / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR / distance geometry | ||||||
データ登録者 | Li, M.F. / Liu, J.X. / Song, J.X. | ||||||
引用 | ジャーナル: Protein Sci. / 年: 2006 タイトル: Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration 著者: Li, M.F. / Liu, J.X. / Song, J.X. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 2g31.cif.gz | 355.7 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb2g31.ent.gz | 296.2 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 2g31.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 2g31_validation.pdf.gz | 341.3 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 2g31_full_validation.pdf.gz | 499.8 KB | 表示 | |
XML形式データ | 2g31_validation.xml.gz | 26.3 KB | 表示 | |
CIF形式データ | 2g31_validation.cif.gz | 38.5 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/g3/2g31 ftp://data.pdbj.org/pub/pdb/validation_reports/g3/2g31 | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 6888.815 Da / 分子数: 1 / 断片: C_terminal domain / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 組織: BRAIN / 遺伝子: NOGO / プラスミド: PET32A / 生物種 (発現宿主): Escherichia coli / 発現宿主: Escherichia coli BL21 (大腸菌) / 株 (発現宿主): BL21 / 参照: UniProt: Q9NQC3 |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||
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NMR実験 |
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-試料調製
詳細 | 内容: 90% H2O, 10% D2O / 溶媒系: 90% H2O/10% D2O |
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試料状態 | pH: 4.0 / 圧: ambient / 温度: 278 K |
-NMR測定
NMRスペクトロメーター | タイプ: Bruker INOVA / 製造業者: Bruker / モデル: INOVA / 磁場強度: 800 MHz |
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-解析
NMR software | 名称: DYANA / バージョン: CYANA 1.0.6 / 開発者: Peter Guntert / 分類: 精密化 |
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精密化 | 手法: distance geometry / ソフトェア番号: 1 |
代表構造 | 選択基準: closest to the average |
NMRアンサンブル | コンフォーマー選択の基準: target function / 計算したコンフォーマーの数: 200 / 登録したコンフォーマーの数: 20 |