- PDB-2f2l: Crystal structure of tracheal cytotoxin (TCT) bound to the ectodo... -
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基本情報
登録情報
データベース: PDB / ID: 2f2l
タイトル
Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)
要素
Peptidoglycan recognition protein-LC isoform LCx
Peptidoglycan-recognition protein-LC isoform LCa
キーワード
MEMBRANE PROTEIN / IMMUNE SYSTEM / TOXIN / Protein-peptidoglycan complex
機能・相同性
機能・相同性情報
regulation of melanization defense response / Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE / Peptidoglycan bound PGRP-LC/LE oligomerises / Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' / Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' / REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' / Phosphorylated REL is cleaved by and dissociates from DREDD / peptidoglycan recognition protein signaling pathway / positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria / positive regulation of antibacterial peptide biosynthetic process ...regulation of melanization defense response / Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE / Peptidoglycan bound PGRP-LC/LE oligomerises / Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' / Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' / REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' / Phosphorylated REL is cleaved by and dissociates from DREDD / peptidoglycan recognition protein signaling pathway / positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria / positive regulation of antibacterial peptide biosynthetic process / regulation of humoral immune response / lipopolysaccharide immune receptor activity / peptidoglycan immune receptor activity / apicolateral plasma membrane / peptidoglycan binding / detection of bacterium / response to bacterium / regulation of synaptic plasticity / presynapse / antibacterial humoral response / cytoplasmic vesicle / defense response to Gram-negative bacterium / defense response to virus / defense response to Gram-positive bacterium / immune response / innate immune response / zinc ion binding / membrane / plasma membrane 類似検索 - 分子機能
Peptidoglycan recognition protein family domain, metazoa/bacteria / Peptidoglycan recognition protein / Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. / Lysozyme-like / Peptidoglycan recognition protein-like / N-acetylmuramoyl-L-alanine amidase / N-acetylmuramoyl-L-alanine amidase domain / N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
解像度: 2.1→30 Å / Cor.coef. Fo:Fc: 0.96 / Cor.coef. Fo:Fc free: 0.934 / SU B: 8.604 / SU ML: 0.12 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.203 / ESU R Free: 0.172 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.21378
1148
5.1 %
RANDOM
Rwork
0.1663
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all
0.16872
22645
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obs
0.16872
21203
98.55 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK