- PDB-2ej8: Crystal structure of APPL1 PTB domain at 1.8A -
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IDまたはキーワード:
読み込み中...
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基本情報
登録情報
データベース: PDB / ID: 2ej8
タイトル
Crystal structure of APPL1 PTB domain at 1.8A
要素
DCC-interacting protein 13 alpha
キーワード
STRUCTURAL GENOMICS / UNKNOWN FUNCTION / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
機能・相同性
機能・相同性情報
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis / positive regulation of macropinocytosis / adiponectin-activated signaling pathway / macropinosome / regulation of fibroblast migration / regulation of glucose import / protein kinase B binding / maintenance of synapse structure / signaling / positive regulation of melanin biosynthetic process ...negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis / positive regulation of macropinocytosis / adiponectin-activated signaling pathway / macropinosome / regulation of fibroblast migration / regulation of glucose import / protein kinase B binding / maintenance of synapse structure / signaling / positive regulation of melanin biosynthetic process / regulation of toll-like receptor 4 signaling pathway / early phagosome / positive regulation of cytokine production involved in inflammatory response / Caspase activation via Dependence Receptors in the absence of ligand / vesicle membrane / cellular response to hepatocyte growth factor stimulus / intracellular vesicle / regulation of innate immune response / beta-tubulin binding / phosphatidylserine binding / regulation of G1/S transition of mitotic cell cycle / regulation of protein localization to plasma membrane / ruffle / phosphatidylinositol binding / transforming growth factor beta receptor signaling pathway / positive regulation of glucose import / protein import into nucleus / insulin receptor signaling pathway / presynapse / early endosome membrane / cytoplasmic vesicle / postsynapse / early endosome / endosome membrane / endosome / glutamatergic synapse / protein-containing complex binding / signal transduction / protein homodimerization activity / extracellular exosome / identical protein binding / membrane / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能
APPL1, BAR domain / : / : / : / BAR domain of APPL family / BAR domain / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain ...APPL1, BAR domain / : / : / : / BAR domain of APPL family / BAR domain / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / AH/BAR domain superfamily / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / PH-like domain superfamily / Roll / Mainly Beta 類似検索 - ドメイン・相同性
解像度: 1.84→1.92 Å / 冗長度: 2.5 % / Rmerge(I) obs: 0.455 / Mean I/σ(I) obs: 2.73783 / Num. unique all: 1784 / Rsym value: 0.331 / % possible all: 91.4
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解析
ソフトウェア
名称
バージョン
分類
REFMAC
5.1.24
精密化
HKL-2000
データ収集
DENZO
データ削減
SCALEPACK
データスケーリング
SnB
位相決定
精密化
構造決定の手法: 単波長異常分散 / 解像度: 1.84→50 Å / Cor.coef. Fo:Fc: 0.945 / Cor.coef. Fo:Fc free: 0.921 / SU B: 3.075 / SU ML: 0.093 / 交差検証法: THROUGHOUT / σ(F): 3 / σ(I): 0 / ESU R: 0.142 / ESU R Free: 0.133 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.; ANOMALOUS DATA WAS USED IN THE REFINEMENT. THE FRIEDEL PAIRS WERE USED FOR POHASING.
Rfactor
反射数
%反射
Selection details
Rfree
0.23014
1280
5.1 %
RANDOM
Rwork
0.19332
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obs
0.19526
23949
99.79 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: BABINET MODEL WITH MASK