- PDB-2ej4: Functional and structural basis of nuclear localization signal in... -
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Basic information
Entry
Database: PDB / ID: 2ej4
Title
Functional and structural basis of nuclear localization signal in ZIC3 zinc finger domain: a role of conserved tryptophan residue in the zinc finger domain
Components
Zinc finger protein ZIC 3
Keywords
GENE REGULATION / zf-C2H2 domain / zinc binding / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
central nervous system segmentation / determination of left/right asymmetry in nervous system / determination of pancreatic left/right asymmetry / determination of digestive tract left/right asymmetry / determination of liver left/right asymmetry / atrial cardiac muscle tissue development / neural plate development / primitive streak formation / POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation / left/right axis specification ...central nervous system segmentation / determination of left/right asymmetry in nervous system / determination of pancreatic left/right asymmetry / determination of digestive tract left/right asymmetry / determination of liver left/right asymmetry / atrial cardiac muscle tissue development / neural plate development / primitive streak formation / POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation / left/right axis specification / germ-line stem cell population maintenance / limb morphogenesis / Transcriptional regulation of pluripotent stem cells / cranial skeletal system development / paraxial mesoderm development / olfactory bulb development / embryonic pattern specification / axial mesoderm development / outer ear morphogenesis / determination of left/right symmetry / smoothened signaling pathway / heart looping / face development / lung development / skeletal system development / central nervous system development / mRNA transcription by RNA polymerase II / stem cell differentiation / hippocampus development / neuron differentiation / sequence-specific double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / sequence-specific DNA binding / transcription coactivator activity / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytoplasm Similarity search - Function
Conformer selection criteria: structures with the least restraint violations,structures with the lowest energy,target function Conformers calculated total number: 100 / Conformers submitted total number: 20
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