- PDB-2e73: Solution structure of the phorbol esters/diacylglycerol binding d... -
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Basic information
Entry
Database: PDB / ID: 2.0E+73
Title
Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma
Components
Protein kinase C gamma type
Keywords
TRANSFERASE / C1 domain / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
Disinhibition of SNARE formation / Response to elevated platelet cytosolic Ca2+ / regulation of response to food / calcium,diacylglycerol-dependent serine/threonine kinase activity / positive regulation of mismatch repair / Trafficking of GluR2-containing AMPA receptors / WNT5A-dependent internalization of FZD4 / protein kinase C / chemosensory behavior / negative regulation of proteasomal protein catabolic process ...Disinhibition of SNARE formation / Response to elevated platelet cytosolic Ca2+ / regulation of response to food / calcium,diacylglycerol-dependent serine/threonine kinase activity / positive regulation of mismatch repair / Trafficking of GluR2-containing AMPA receptors / WNT5A-dependent internalization of FZD4 / protein kinase C / chemosensory behavior / negative regulation of proteasomal protein catabolic process / diacylglycerol-dependent serine/threonine kinase activity / innervation / regulation of phagocytosis / presynaptic cytosol / response to morphine / Calmodulin induced events / postsynaptic cytosol / response to psychosocial stress / regulation of synaptic vesicle exocytosis / response to pain / calyx of Held / negative regulation of protein ubiquitination / presynaptic modulation of chemical synaptic transmission / protein serine/threonine/tyrosine kinase activity / synaptic membrane / long-term synaptic potentiation / regulation of circadian rhythm / negative regulation of protein catabolic process / response to toxic substance / G alpha (z) signalling events / cell-cell junction / rhythmic process / chemical synaptic transmission / negative regulation of neuron apoptotic process / postsynaptic density / learning or memory / protein kinase activity / intracellular signal transduction / phosphorylation / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / dendrite / perinuclear region of cytoplasm / zinc ion binding / ATP binding / nucleus / plasma membrane / cytosol Similarity search - Function
Protein kinase C, alpha/beta/gamma types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) ...Protein kinase C, alpha/beta/gamma types / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
Conformer selection criteria: structures with the least restraint violations, structures with the lowest energy, target function Conformers calculated total number: 100 / Conformers submitted total number: 20
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