- PDB-2d8t: Solution structure of the RING domain of the human RING finger pr... -
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Basic information
Entry
Database: PDB / ID: 2d8t
Title
Solution structure of the RING domain of the human RING finger protein 146
Components
RING finger protein 146
Keywords
METAL BINDING PROTEIN / RING finger protein 146 / Dactylidin / RNF146 / RING domain / structural genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
poly-ADP-D-ribose binding / protein K48-linked ubiquitination / protein autoubiquitination / TCF dependent signaling in response to WNT / Degradation of AXIN / RING-type E3 ubiquitin transferase / Wnt signaling pathway / Regulation of PTEN stability and activity / ubiquitin-protein transferase activity / ubiquitin protein ligase activity ...poly-ADP-D-ribose binding / protein K48-linked ubiquitination / protein autoubiquitination / TCF dependent signaling in response to WNT / Degradation of AXIN / RING-type E3 ubiquitin transferase / Wnt signaling pathway / Regulation of PTEN stability and activity / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / positive regulation of canonical Wnt signaling pathway / ubiquitin-dependent protein catabolic process / Ub-specific processing proteases / zinc ion binding / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function
E3 ubiquitin-protein ligase RNF146 / RNF146, RING finger, HC subclass / WWE domain, subgroup / Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis. / WWE domain / WWE domain superfamily / WWE domain / WWE domain profile. / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site ...E3 ubiquitin-protein ligase RNF146 / RNF146, RING finger, HC subclass / WWE domain, subgroup / Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis. / WWE domain / WWE domain superfamily / WWE domain / WWE domain profile. / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type Similarity search - Domain/homology
Conformer selection criteria: target function, structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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