登録情報 | データベース: PDB / ID: 2d60 |
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タイトル | Crystal structure of deoxy human hemoglobin complexed with two L35 molecules |
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要素 | - Hemoglobin alpha subunit
- Hemoglobin beta subunit
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キーワード | OXYGEN STORAGE/TRANSPORT / HEMOGLOBIN / L35 / ALLOSTERIC EFFECTOR / CRYSTAL SRUCTURE / OXYGEN STORAGE-TRANSPORT COMPLEX |
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機能・相同性 | 機能・相同性情報
nitric oxide transport / hemoglobin binding / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ...nitric oxide transport / hemoglobin binding / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / Heme signaling / carbon dioxide transport / response to hydrogen peroxide / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / Cytoprotection by HMOX1 / oxygen binding / regulation of blood pressure / platelet aggregation / Chaperone Mediated Autophagy / peroxidase activity / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin / Globin-like superfamily ...Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin / Globin-like superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / Chem-L35 / Hemoglobin subunit beta / Hemoglobin subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
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データ登録者 | Yokoyama, T. / Neya, S. / Tsuneshige, A. / Yonetani, T. / Park, S.Y. / Tame, J.R. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2006 タイトル: R-state haemoglobin with low oxygen affinity: crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35 著者: Yokoyama, T. / Neya, S. / Tsuneshige, A. / Yonetani, T. / Park, S.Y. / Tame, J.R. |
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履歴 | 登録 | 2005年11月8日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2006年3月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2024年3月13日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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