Entry Database : PDB / ID : 2czy Structure visualization Downloads & linksTitle Solution structure of the NRSF/REST-mSin3B PAH1 complex ComponentsPaired amphipathic helix protein Sin3b transcription factor REST (version 3) DetailsKeywords GENE REGULATION / NRSF / Sin3 / PAH1 / transcriptional repressorFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of dense core granule biogenesis / negative regulation of amniotic stem cell differentiation / autosome / negative regulation of aldosterone biosynthetic process / negative regulation of cortisol biosynthetic process / negative regulation of transcription regulatory region DNA binding / modification of synaptic structure / Regulation of NPAS4 gene transcription / cellular response to electrical stimulus / negative regulation of mesenchymal stem cell differentiation ... negative regulation of dense core granule biogenesis / negative regulation of amniotic stem cell differentiation / autosome / negative regulation of aldosterone biosynthetic process / negative regulation of cortisol biosynthetic process / negative regulation of transcription regulatory region DNA binding / modification of synaptic structure / Regulation of NPAS4 gene transcription / cellular response to electrical stimulus / negative regulation of mesenchymal stem cell differentiation / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / detection of mechanical stimulus involved in sensory perception of sound / Regulation of lipid metabolism by PPARalpha / negative regulation of calcium ion-dependent exocytosis / Cytoprotection by HMOX1 / cardiac muscle cell myoblast differentiation / neuronal stem cell population maintenance / XY body / NGF-stimulated transcription / cardiac muscle tissue development / positive regulation of programmed cell death / auditory receptor cell stereocilium organization / nervous system process / cellular response to glucocorticoid stimulus / regulation of osteoblast differentiation / positive regulation of stem cell population maintenance / Y chromosome / X chromosome / regulation of alternative mRNA splicing, via spliceosome / somatic stem cell population maintenance / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / neuromuscular process controlling balance / histone deacetylase complex / negative regulation of cell cycle / negative regulation of neuron differentiation / negative regulation by host of viral transcription / RNA polymerase II core promoter sequence-specific DNA binding / negative regulation of insulin secretion / hematopoietic progenitor cell differentiation / skeletal muscle tissue development / transcription repressor complex / positive regulation of neuron differentiation / negative regulation of cell migration / negative regulation of miRNA transcription / Regulation of PTEN gene transcription / response to ischemia / HDACs deacetylate histones / DNA-binding transcription repressor activity, RNA polymerase II-specific / negative regulation of neurogenesis / transcription corepressor activity / cellular response to xenobiotic stimulus / RNA polymerase II-specific DNA-binding transcription factor binding / Potential therapeutics for SARS / transcription cis-regulatory region binding / response to hypoxia / chromatin remodeling / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of gene expression / regulation of DNA-templated transcription / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function Paired amphipathic helix / Paired amphipathic helix 2 (pah2 repeat) / Histone deacetylase interacting domain / Sin3, C-terminal / Transcriptional regulatory protein Sin3-like / Sin3 family co-repressor / C-terminal domain of Sin3a protein / Histone deacetylase (HDAC) interacting / Paired amphipathic helix / Paired amphipathic helix superfamily ... Paired amphipathic helix / Paired amphipathic helix 2 (pah2 repeat) / Histone deacetylase interacting domain / Sin3, C-terminal / Transcriptional regulatory protein Sin3-like / Sin3 family co-repressor / C-terminal domain of Sin3a protein / Histone deacetylase (HDAC) interacting / Paired amphipathic helix / Paired amphipathic helix superfamily / Paired amphipathic helix repeat / PAH domain profile. / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method SOLUTION NMR / simulated annealing DetailsAuthors Nomura, M. / Uda-Tochio, H. / Murai, K. / Mori, N. / Nishimura, Y. CitationJournal : J.Mol.Biol. / Year : 2005Title : The Neural Repressor NRSF/REST Binds the PAH1 Domain of the Sin3 Corepressor by Using its Distinct Short Hydrophobic HelixAuthors : Nomura, M. / Uda-Tochio, H. / Murai, K. / Mori, N. / Nishimura, Y. History Deposition Jul 20, 2005 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Dec 20, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Oct 21, 2007 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Mar 9, 2022 Group : Data collection / Database references / Derived calculationsCategory : database_2 / pdbx_nmr_spectrometer ... database_2 / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.modelRevision 1.4 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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