登録情報 | データベース: PDB / ID: 2cue |
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タイトル | Solution structure of the homeobox domain of the human paired box protein Pax-6 |
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要素 | Paired box protein Pax6Pax遺伝子 |
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キーワード | TRANSCRIPTION (転写 (生物学)) / homeobox domain (ホメオボックス) / paired box protein (Pax遺伝子) / Pax6 / transcription factor (転写因子) / Structural Genomics (構造ゲノミクス) / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI |
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機能・相同性 | 機能・相同性情報
pancreatic A cell development / rhombomere morphogenesis / oligodendrocyte cell fate specification / forebrain-midbrain boundary formation / learned vocalization behavior or vocal learning / positive regulation of glutamatergic neuron differentiation / sensory neuron migration / commitment of neuronal cell to specific neuron type in forebrain / type B pancreatic cell differentiation / cerebral cortex regionalization ...pancreatic A cell development / rhombomere morphogenesis / oligodendrocyte cell fate specification / forebrain-midbrain boundary formation / learned vocalization behavior or vocal learning / positive regulation of glutamatergic neuron differentiation / sensory neuron migration / commitment of neuronal cell to specific neuron type in forebrain / type B pancreatic cell differentiation / cerebral cortex regionalization / olfactory bulb mitral cell layer development / habenula development / forebrain dorsal/ventral pattern formation / cornea development in camera-type eye / regulation of timing of cell differentiation / HMG box domain binding / positive regulation of cell fate specification / iris morphogenesis / interkinetic nuclear migration / Formation of the anterior neural plate / positive regulation of epithelial cell differentiation / regulation of asymmetric cell division / embryonic camera-type eye morphogenesis / ventral spinal cord development / lacrimal gland development / co-SMAD binding / protein localization to organelle / pituitary gland development / eye photoreceptor cell development / anatomical structure development / dorsal/ventral axis specification / insulin metabolic process / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / positive regulation of core promoter binding / neuron fate commitment / eye development / : / positive regulation of neuron migration / : / 拘束 (生物学) / signal transduction involved in regulation of gene expression / astrocyte differentiation / cellular response to fibroblast growth factor stimulus / 神経堤 / lens development in camera-type eye / regulation of neuron projection development / negative regulation of neuroblast proliferation / histone acetyltransferase binding / smoothened signaling pathway / positive regulation of neuroblast proliferation / blood vessel development / minor groove of adenine-thymine-rich DNA binding / establishment of mitotic spindle orientation / R-SMAD binding / Regulation of gene expression in beta cells / negative regulation of neuron differentiation / neuroblast proliferation / RNA polymerase II core promoter sequence-specific DNA binding / salivary gland morphogenesis / keratinocyte differentiation / 視覚 / cerebellum development / negative regulation of protein phosphorylation / cellular response to leukemia inhibitory factor / central nervous system development / transcription coregulator binding / cellular response to glucose stimulus / 軸索誘導 / animal organ morphogenesis / chromatin DNA binding / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / negative regulation of neurogenesis / response to wounding / Activation of anterior HOX genes in hindbrain development during early embryogenesis / cellular response to prostaglandin E stimulus / cellular response to insulin stimulus / negative regulation of epithelial cell proliferation / sequence-specific double-stranded DNA binding / cellular response to xenobiotic stimulus / retina development in camera-type eye / glucose homeostasis / nervous system development / DNA-binding transcription activator activity, RNA polymerase II-specific / response to ethanol / transcription by RNA polymerase II / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / クロマチンリモデリング / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / ubiquitin protein ligase binding / クロマチン / positive regulation of gene expression / regulation of transcription by RNA polymerase II / protein kinase binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II類似検索 - 分子機能 Pax遺伝子 / Paired DNA-binding domain / PAX family / 'Paired box' domain / Paired DNA-binding domain signature. / Paired DNA-binding domain profile. / Paired Box domain / Homeobox, conserved site / 'Homeobox' domain signature. / ホメオボックス ...Pax遺伝子 / Paired DNA-binding domain / PAX family / 'Paired box' domain / Paired DNA-binding domain signature. / Paired DNA-binding domain profile. / Paired Box domain / Homeobox, conserved site / 'Homeobox' domain signature. / ホメオボックス / 'Homeobox' domain profile. / ホメオボックス / Homeobox domain / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics, restrained molecular dynamics |
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データ登録者 | Ohnishi, S. / Kigawa, T. / Tochio, N. / Tomizawa, T. / Koshiba, S. / Inoue, M. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) |
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引用 | ジャーナル: To be Published タイトル: Solution structure of the homeobox domain of the human paired box protein Pax-6 著者: Ohnishi, S. / Kigawa, T. / Tochio, N. / Tomizawa, T. / Koshiba, S. / Inoue, M. / Yokoyama, S. |
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履歴 | 登録 | 2005年5月26日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2005年11月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2022年3月9日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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改定 1.4 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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Remark 650 | HELIX Determination method: author determined |
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