- PDB-2csw: Solution structure of the FHA domain of human ubiquitin ligase pr... -
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Basic information
Entry
Database: PDB / ID: 2csw
Title
Solution structure of the FHA domain of human ubiquitin ligase protein RNF8
Components
Ubiquitin ligase protein RNF8
Keywords
LIGASE / 11-stranded beta sandwich / RING finger protein 8 / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
sperm DNA condensation / protein K6-linked ubiquitination / isotype switching / DNA repair-dependent chromatin remodeling / response to ionizing radiation / negative regulation of transcription elongation by RNA polymerase II / protein K63-linked ubiquitination / positive regulation of double-strand break repair via homologous recombination / signal transduction in response to DNA damage / protein K48-linked ubiquitination ...sperm DNA condensation / protein K6-linked ubiquitination / isotype switching / DNA repair-dependent chromatin remodeling / response to ionizing radiation / negative regulation of transcription elongation by RNA polymerase II / protein K63-linked ubiquitination / positive regulation of double-strand break repair via homologous recombination / signal transduction in response to DNA damage / protein K48-linked ubiquitination / protein autoubiquitination / interstrand cross-link repair / ubiquitin ligase complex / positive regulation of DNA repair / epigenetic regulation of gene expression / ubiquitin binding / Nonhomologous End-Joining (NHEJ) / RING-type E3 ubiquitin transferase / G2/M DNA damage checkpoint / double-strand break repair via nonhomologous end joining / ubiquitin protein ligase activity / double-strand break repair / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / site of double-strand break / Processing of DNA double-strand break ends / histone binding / midbody / ubiquitin-dependent protein catabolic process / chromosome, telomeric region / cell division / ubiquitin protein ligase binding / DNA damage response / chromatin binding / protein homodimerization activity / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol Similarity search - Function
Conformer selection criteria: target function, structures with the lowest energy, structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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