- PDB-2crh: Solution structure of the SH2 domain of human proto-oncogene prot... -
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基本情報
登録情報
データベース: PDB / ID: 2crh
タイトル
Solution structure of the SH2 domain of human proto-oncogene protein VAV1
要素
Vav proto-oncogene
キーワード
SIGNALING PROTEIN / ONCOPROTEIN / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
機能・相同性
機能・相同性情報
phosphorylation-dependent protein binding / positive regulation of natural killer cell mediated cytotoxicity / Azathioprine ADME / regulation of small GTPase mediated signal transduction / CD28 dependent Vav1 pathway / natural killer cell mediated cytotoxicity / regulation of cell size / regulation of GTPase activity / Fc-gamma receptor signaling pathway involved in phagocytosis / NRAGE signals death through JNK ...phosphorylation-dependent protein binding / positive regulation of natural killer cell mediated cytotoxicity / Azathioprine ADME / regulation of small GTPase mediated signal transduction / CD28 dependent Vav1 pathway / natural killer cell mediated cytotoxicity / regulation of cell size / regulation of GTPase activity / Fc-gamma receptor signaling pathway involved in phagocytosis / NRAGE signals death through JNK / Fc-epsilon receptor signaling pathway / T cell differentiation / Interleukin-3, Interleukin-5 and GM-CSF signaling / RHOG GTPase cycle / RHOA GTPase cycle / RAC2 GTPase cycle / vascular endothelial growth factor receptor signaling pathway / Erythropoietin activates RAS / GPVI-mediated activation cascade / T cell costimulation / RAC1 GTPase cycle / neutrophil chemotaxis / phosphotyrosine residue binding / reactive oxygen species metabolic process / FCERI mediated Ca+2 mobilization / VEGFR2 mediated vascular permeability / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / guanyl-nucleotide exchange factor activity / integrin-mediated signaling pathway / Regulation of signaling by CBL / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / Signaling by SCF-KIT / platelet activation / Regulation of actin dynamics for phagocytic cup formation / VEGFA-VEGFR2 Pathway / Constitutive Signaling by Aberrant PI3K in Cancer / G alpha (12/13) signalling events / cell-cell junction / cellular response to xenobiotic stimulus / cell migration / PIP3 activates AKT signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Potential therapeutics for SARS / intracellular signal transduction / G protein-coupled receptor signaling pathway / metal ion binding / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能
コンフォーマー選択の基準: target function, structures with the lowest energy, structures with the least restraint violations 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 20