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Yorodumi- PDB-2bgn: HIV-1 Tat protein derived N-terminal nonapeptide Trp2-Tat(1-9) bo... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2bgn | |||||||||
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Title | HIV-1 Tat protein derived N-terminal nonapeptide Trp2-Tat(1-9) bound to the active site of Dipeptidyl peptidase IV (CD26) | |||||||||
Components |
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Keywords | HYDROLASE / HYDROLASE-COMPLEX / DIPETIDYL PEPTIDASE IV / DPPIV / CD26 / ALPHA/BETA-HYDROLASE FOLD / BETA-PROPELLER FOLD / PROTEIN-PROTEIN COMPLEX / ADENOSINE DEAMINASE / ADA / SERINE PROTEASE / AMINOPEPTIDASE / HIV-1 TAT PROTEIN | |||||||||
Function / homology | Function and homology information viral gene expression / trans-activation response element binding / negative regulation of adenosine receptor signaling pathway / protein serine/threonine phosphatase inhibitor activity / cytoplasmic vesicle lumen / inosine biosynthetic process / regulatory region RNA binding / 2'-deoxyadenosine deaminase activity / adenosine deaminase / positive regulation of viral transcription ...viral gene expression / trans-activation response element binding / negative regulation of adenosine receptor signaling pathway / protein serine/threonine phosphatase inhibitor activity / cytoplasmic vesicle lumen / inosine biosynthetic process / regulatory region RNA binding / 2'-deoxyadenosine deaminase activity / adenosine deaminase / positive regulation of viral transcription / adenosine catabolic process / adenosine deaminase activity / hypoxanthine salvage / purine ribonucleoside monophosphate biosynthetic process / glucagon processing / modulation by virus of host chromatin organization / negative regulation of neutrophil chemotaxis / symbiont-mediated suppression of host translation initiation / regulation of cell-cell adhesion mediated by integrin / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV / host cell nucleolus / intercellular canaliculus / chemorepellent activity / nucleotide metabolic process / actinin binding / dipeptidyl-peptidase activity / peptide hormone processing / anchoring junction / negative regulation of peptidyl-threonine phosphorylation / locomotory exploration behavior / lamellipodium membrane / endocytic vesicle / endothelial cell migration / RNA-binding transcription regulator activity / behavioral fear response / aminopeptidase activity / T cell costimulation / T cell activation / serine-type peptidase activity / cyclin binding / positive regulation of transcription elongation by RNA polymerase II / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / lamellipodium / virus receptor activity / protease binding / host cell cytoplasm / receptor-mediated endocytosis of virus by host cell / membrane fusion / receptor-mediated virion attachment to host cell / lysosome / response to hypoxia / symbiont-mediated suppression of host innate immune response / cell adhesion / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / symbiont entry into host cell / apical plasma membrane / membrane raft / protein domain specific binding / external side of plasma membrane / lysosomal membrane / serine-type endopeptidase activity / signaling receptor binding / focal adhesion / virus-mediated perturbation of host defense response / DNA-templated transcription / positive regulation of cell population proliferation / apoptotic process / cell surface / protein homodimerization activity / proteolysis / extracellular exosome / zinc ion binding / extracellular region / identical protein binding / membrane / metal ion binding / plasma membrane / cytosol Similarity search - Function | |||||||||
Biological species | HOMO SAPIENS (human) BOS TAURUS (cattle) HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.15 Å | |||||||||
Authors | Weihofen, W.A. / Liu, J. / Reutter, W. / Saenger, W. / Fan, H. | |||||||||
Citation | Journal: J.Biol.Chem. / Year: 2005 Title: Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26) Authors: Weihofen, W.A. / Liu, J. / Reutter, W. / Saenger, W. / Fan, H. | |||||||||
History |
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Remark 700 | SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED. |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2bgn.cif.gz | 869.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2bgn.ent.gz | 721.3 KB | Display | PDB format |
PDBx/mmJSON format | 2bgn.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/bg/2bgn ftp://data.pdbj.org/pub/pdb/validation_reports/bg/2bgn | HTTPS FTP |
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-Related structure data
Related structure data | 2bgrC 1w1iS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
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-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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