登録情報 データベース : PDB / ID : 2b8l 構造の表示 ダウンロードとリンクタイトル Crystal structure of human beta secretase complexed with inhibitor 要素Beta-secretase 1 詳細 キーワード HYDROLASE / ASPARTYL PROTEASE / BACE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 単波長異常分散 / 解像度 : 1.7 Å 詳細データ登録者 Munshi, S.K. / Kuo, L. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2006タイトル : Conformationally biased P3 amide replacements of beta-secretase inhibitors著者 : Stachel, S.J. / Coburn, C.A. / Steele, T.G. / Crouthamel, M.C. / Pietrak, B.L. / Lai, M.T. / Holloway, M.K. / Munshi, S.K. / Graham, S.L. / Vacca, J.P. 履歴 登録 2005年10月7日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2005年10月18日 Provider : repository / タイプ : Initial release改定 1.1 2007年10月11日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2021年10月20日 Group : Database references / Derived calculations / カテゴリ : database_2 / struct_ref_seq_dif / struct_siteItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.4 2023年8月23日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
すべて表示 表示を減らす Remark 300 BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 1 ... BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 1 CHAIN(S). SOME REPORTS INDICATE THAT THE BIOLOGICAL UNIT FOR THE PROTEIN IS A DIMER. HOWEVER, THE TRUNCATED BACE IS FULLY FUNCTIONAL AS A MONOMER IN SOLUTION.