Entry | Database: PDB / ID: 2aw5 |
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Title | Crystal structure of a human malic enzyme |
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Components | NADP-dependent malic enzyme |
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Keywords | OXIDOREDUCTASE / Rossmann fold / Structural Genomics / Structural Genomics Consortium / SGC |
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Function / homology | Function and homology information
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) / regulation of NADP metabolic process / malic enzyme activity / malate dehydrogenase (decarboxylating) (NADP+) activity / nucleotide biosynthetic process / NFE2L2 regulating TCA cycle genes / oxaloacetate decarboxylase activity / Pyruvate metabolism / malate metabolic process / NADP metabolic process ...malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) / regulation of NADP metabolic process / malic enzyme activity / malate dehydrogenase (decarboxylating) (NADP+) activity / nucleotide biosynthetic process / NFE2L2 regulating TCA cycle genes / oxaloacetate decarboxylase activity / Pyruvate metabolism / malate metabolic process / NADP metabolic process / response to carbohydrate / NADH metabolic process / pyruvate metabolic process / response to hormone / PPARA activates gene expression / ADP binding / NAD binding / NADP binding / manganese ion binding / protein homotetramerization / carbohydrate metabolic process / electron transfer activity / magnesium ion binding / mitochondrion / identical protein binding / cytoplasm / cytosolSimilarity search - Function Malic enzyme, N-terminal domain / Malic enzyme, conserved site / Malic enzymes signature. / Malic oxidoreductase / Malic enzyme, N-terminal domain / Malic enzyme, N-terminal domain / Malic enzyme, NAD-binding / Malic enzyme, N-terminal domain superfamily / Malic enzyme, N-terminal domain / Malic enzyme, NAD binding domain ...Malic enzyme, N-terminal domain / Malic enzyme, conserved site / Malic enzymes signature. / Malic oxidoreductase / Malic enzyme, N-terminal domain / Malic enzyme, N-terminal domain / Malic enzyme, NAD-binding / Malic enzyme, N-terminal domain superfamily / Malic enzyme, N-terminal domain / Malic enzyme, NAD binding domain / Malic enzyme, NAD binding domain / Aminoacid dehydrogenase-like, N-terminal domain superfamily / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.5 Å |
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Authors | Papagrigoriou, E. / Berridge, G. / Smee, C. / Bray, J. / Arrowsmith, C. / Edwards, A. / Weigelt, J. / Sundstrom, M. / Oppermann, U. / Gileadi, O. ...Papagrigoriou, E. / Berridge, G. / Smee, C. / Bray, J. / Arrowsmith, C. / Edwards, A. / Weigelt, J. / Sundstrom, M. / Oppermann, U. / Gileadi, O. / von Delft, F. / Structural Genomics Consortium (SGC) |
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Citation | Journal: To be published Title: Crystal structure of a human malic enzyme Authors: Papagrigoriou, E. / Berridge, G. / Smee, C. / Bray, J. / Arrowsmith, C. / Edwards, A. / Weigelt, J. / Sundstrom, M. / Oppermann, U. / Gileadi, O. / von Delft, F. |
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History | Deposition | Aug 31, 2005 | Deposition site: RCSB / Processing site: PDBJ |
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Revision 1.0 | Sep 20, 2005 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 1, 2008 | Group: Version format compliance |
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Revision 1.2 | Jul 13, 2011 | Group: Version format compliance |
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Revision 1.3 | Mar 13, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ref_seq_dif.details |
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