- PDB-2abm: Crystal Structure of Aquaporin Z Tetramer Reveals both Open and C... -
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Basic information
Entry
Database: PDB / ID: 2abm
Title
Crystal Structure of Aquaporin Z Tetramer Reveals both Open and Closed Water-conducting Channels
Components
Aquaporin Z
Keywords
MEMBRANE PROTEIN / AQUAPORIN
Function / homology
Function and homology information
water channel activity / intracellular water homeostasis / water transport / response to osmotic stress / identical protein binding / plasma membrane Similarity search - Function
Aquaporin Z / Glycerol uptake facilitator protein / Glycerol uptake facilitator protein. / Aquaporin transporter / Major intrinsic protein, conserved site / MIP family signature. / Major intrinsic protein / Major intrinsic protein / Aquaporin-like / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology
3-PHOSPHOGLYCERIC ACID / Chem-AGA / 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / PHOSPHATE ION / Chem-POQ / Aquaporin Z Similarity search - Component
Journal: J.Biol.Chem. / Year: 2006 Title: Crystal Structure of AqpZ Tetramer Reveals Two Distinct Arg-189 Conformations Associated with Water Permeation through the Narrowest Constriction of the Water-conducting Channel. Authors: Jiang, J. / Daniels, B.V. / Fu, D.
NON-CRYSTALLOGRAPHIC SYMMETRY THE TRANSFORMATIONS PRESENTED ON THE MTRIX RECORDS BELOW DESCRIBE ... NON-CRYSTALLOGRAPHIC SYMMETRY THE TRANSFORMATIONS PRESENTED ON THE MTRIX RECORDS BELOW DESCRIBE NON-CRYSTALLOGRAPHIC RELATIONSHIPS AMONG ATOMS IN THIS ENTRY. APPLYING THE APPROPRIATE MTRIX TRANSFORMATION TO THE RESIDUES LISTED FIRST WILL YIELD APPROXIMATE COORDINATES FOR THE RESIDUES LISTED SECOND. CHAIN IDENTIFIERS GIVEN AS "?" REFER TO CHAINS FOR WHICH ATOMS ARE NOT FOUND IN THIS ENTRY. APPLIED TO TRANSFORMED TO TRANSFORM CHAIN RESIDUES CHAIN RESIDUES RMSD SSS M 1 A 1 .. 227 E 1 .. 227 0.162 M 1 B 1 .. 227 F 1 .. 227 0.170 M 1 C 1 .. 227 G 1 .. 227 0.156 M 1 D 1 .. 227 H 1 .. 227 0.158 WHERE SSS -> COLUMNS 8-10 OF MTRIX RECORDS REMARK:
Remark 600
HETEROGEN ATOMS FOR SEVERAL LIGANDS WERE MISSING IN THE DENSITY. THE LIGANDS IN QUESTION ARE: BGL ...HETEROGEN ATOMS FOR SEVERAL LIGANDS WERE MISSING IN THE DENSITY. THE LIGANDS IN QUESTION ARE: BGL 604, 608, 605, 609. PEE 602, 606, 612, 613 AGA 629, 639. PEE 603, 607, 611.
The second tetramer (E,F,G,H) and the first tetramer (A,B,C,D) are related by a non-crystallographic 2-fold symmetry as rotation=( 0.57467 0.81768 -0.03404 ) ( 0.81778 -0.57535 -0.01457 ) ( -0.03150 -0.01946 -0.99931 ) translation=( 8.86685 -14.57612 47.95166 )
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Components
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Protein / Sugars , 2 types, 12 molecules ABCDEFGH
#1: Protein
AquaporinZ / Bacterial nodulin-like intrinsic protein
Mass: 23717.662 Da / Num. of mol.: 8 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Escherichia coli (E. coli) / Gene: aqpZ, bniP / Plasmid: pLysS / Species (production host): Escherichia coli / Production host: Escherichia coli BL21 (bacteria) / Strain (production host): BL21 / References: UniProt: P60844
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