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- PDB-1zub: Solution Structure of the RIM1alpha PDZ Domain in Complex with an... -
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Basic information
Entry | Database: PDB / ID: 1zub | ||||||
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Title | Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide | ||||||
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![]() | ENDOCYTOSIS/EXOCYTOSIS / PDZ domain / complex / ENDOCYTOSIS-EXOCYTOSIS COMPLEX | ||||||
Function / homology | ![]() positive regulation of synaptic vesicle priming / positive regulation of synaptic vesicle fusion to presynaptic active zone membrane / extrinsic component of presynaptic active zone membrane / acrosomal vesicle exocytosis / regulation of calcium-dependent activation of synaptic vesicle fusion / structural constituent of presynaptic active zone / maintenance of presynaptic active zone structure / cytoskeleton of presynaptic active zone / IkappaB kinase complex / spontaneous neurotransmitter secretion ...positive regulation of synaptic vesicle priming / positive regulation of synaptic vesicle fusion to presynaptic active zone membrane / extrinsic component of presynaptic active zone membrane / acrosomal vesicle exocytosis / regulation of calcium-dependent activation of synaptic vesicle fusion / structural constituent of presynaptic active zone / maintenance of presynaptic active zone structure / cytoskeleton of presynaptic active zone / IkappaB kinase complex / spontaneous neurotransmitter secretion / Glutamate Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / Dopamine Neurotransmitter Release Cycle / presynaptic dense core vesicle exocytosis / synaptic vesicle docking / inhibitory synapse / calcium ion-regulated exocytosis of neurotransmitter / neuromuscular synaptic transmission / regulation of presynaptic cytosolic calcium ion concentration / presynaptic active zone cytoplasmic component / positive regulation of dendrite extension / positive regulation of inhibitory postsynaptic potential / neurotransmitter secretion / presynaptic cytosol / retrograde transport, endosome to Golgi / synaptic vesicle priming / regulation of synaptic vesicle exocytosis / positive regulation of excitatory postsynaptic potential / GABA-ergic synapse / positive regulation of synaptic transmission / ciliary basal body / cell projection / PDZ domain binding / regulation of membrane potential / long-term synaptic potentiation / intracellular protein transport / regulation of long-term neuronal synaptic plasticity / regulation of synaptic plasticity / small GTPase binding / SH3 domain binding / protein transport / synaptic vesicle / presynaptic membrane / protein-containing complex assembly / vesicle / transmembrane transporter binding / postsynaptic density / cell differentiation / Golgi membrane / centrosome / glutamatergic synapse / synapse / positive regulation of gene expression / regulation of DNA-templated transcription / protein kinase binding / membrane / metal ion binding / plasma membrane / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR / torsion angle dynamics | ||||||
![]() | Lu, J. / Li, H. / Wang, Y. / Sudhof, T.C. / Rizo, J. | ||||||
![]() | ![]() Title: Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide Authors: Lu, J. / Li, H. / Wang, Y. / Sudhof, T.C. / Rizo, J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 700.6 KB | Display | ![]() |
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PDB format | ![]() | 586.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 358.7 KB | Display | ![]() |
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Full document | ![]() | 642.7 KB | Display | |
Data in XML | ![]() | 59.1 KB | Display | |
Data in CIF | ![]() | 76.9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 12244.122 Da / Num. of mol.: 1 / Fragment: PDZ Domain Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() |
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#2: Protein/peptide | Mass: 1294.301 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||
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NMR experiment |
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Sample preparation
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Sample conditions | Ionic strength: 150mM NaCl / pH: 6.5 / Pressure: ambient / Temperature: 303 K |
-NMR measurement
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M | |||||||||||||||
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Radiation wavelength | Relative weight: 1 | |||||||||||||||
NMR spectrometer |
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Processing
NMR software |
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Refinement | Method: torsion angle dynamics / Software ordinal: 1 | ||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 1000 / Conformers submitted total number: 20 |