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Open data
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Basic information
Entry | Database: PDB / ID: 1zgl | ||||||
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Title | Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a | ||||||
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![]() | IMMUNE SYSTEM / TCR-peptide-MHC complex | ||||||
Function / homology | ![]() compact myelin / structural constituent of myelin sheath / positive regulation of metalloendopeptidase activity / : / internode region of axon / axon ensheathment / negative regulation of heterotypic cell-cell adhesion / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane ...compact myelin / structural constituent of myelin sheath / positive regulation of metalloendopeptidase activity / : / internode region of axon / axon ensheathment / negative regulation of heterotypic cell-cell adhesion / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / EGR2 and SOX10-mediated initiation of Schwann cell myelination / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / membrane organization / positive regulation of memory T cell differentiation / alpha-beta T cell receptor complex / positive regulation of chemokine (C-X-C motif) ligand 2 production / transport vesicle membrane / polysaccharide binding / maintenance of blood-brain barrier / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / alpha-beta T cell activation / Generation of second messenger molecules / immunological synapse / PD-1 signaling / T cell receptor binding / immunoglobulin complex, circulating / immunoglobulin receptor binding / substantia nigra development / MHC class II antigen presentation / myelination / trans-Golgi network membrane / complement activation, classical pathway / central nervous system development / cell periphery / lumenal side of endoplasmic reticulum membrane / sensory perception of sound / antigen binding / response to bacterium / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / response to toxic substance / cognition / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / positive regulation of T cell mediated cytotoxicity / positive regulation of interleukin-6 production / peptide antigen binding / endocytic vesicle membrane / antigen processing and presentation of exogenous peptide antigen via MHC class II / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / positive regulation of immune response / MAPK cascade / positive regulation of T cell activation / Downstream TCR signaling / myelin sheath / MHC class II protein complex binding / late endosome membrane / T cell receptor signaling pathway / early endosome membrane / antibacterial humoral response / chemical synaptic transmission / protease binding / adaptive immune response / lysosome / blood microparticle / calmodulin binding / immune response / lysosomal membrane / Golgi membrane / neuronal cell body / lipid binding / synapse / cell surface / protein-containing complex / extracellular exosome / membrane / nucleus / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Li, Y. / Huang, Y. / Lue, J. / Quandt, J.A. / Martin, R. / Mariuzza, R.A. | ||||||
![]() | ![]() Title: Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. Authors: Li, Y. / Huang, Y. / Lue, J. / Quandt, J.A. / Martin, R. / Mariuzza, R.A. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 602 KB | Display | ![]() |
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PDB format | ![]() | 485.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 594.1 KB | Display | ![]() |
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Full document | ![]() | 824.8 KB | Display | |
Data in XML | ![]() | 134.3 KB | Display | |
Data in CIF | ![]() | 179.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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4 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 21084.826 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Protein | Mass: 22446.783 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #3: Protein/peptide | Mass: 1672.946 Da / Num. of mol.: 4 / Source method: obtained synthetically / Source: (synth.) Homo sapiens / References: UniProt: Q6AI64, UniProt: P02686*PLUS #4: Protein | Mass: 22932.279 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #5: Protein | Mass: 27794.729 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.58 Å3/Da / Density % sol: 52.29 % |
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-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() |
Detector | Type: SIEMENS HI-STAR / Detector: AREA DETECTOR / Date: Oct 1, 2004 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Resolution: 2.8→30 Å / Num. all: 177348 / Num. obs: 81551 / % possible obs: 0.863 % / Observed criterion σ(F): 5.9 / Observed criterion σ(I): 5.9 / Rmerge(I) obs: 0.08 / Rsym value: 0.08 |
Reflection shell | Resolution: 2.8→2.92 Å / Rmerge(I) obs: 0.284 / Mean I/σ(I) obs: 2.5 / Rsym value: 0.284 / % possible all: 86.5 |
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Processing
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Refinement | Method to determine structure: ![]()
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Refinement step | Cycle: LAST / Resolution: 2.8→30 Å
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