Entry Database : PDB / ID : 1yuc Structure visualization Downloads & linksTitle Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP ComponentsNuclear receptor 0B2 Orphan nuclear receptor NR5A2 DetailsKeywords TRANSCRIPTION REGULATION / Liver Receptor Homologue 1 / Nuclear Receptor Ligand Binding Domain / LRH-1 / Phospholipid / SHP / Small Heterodimer PartnerFunction / homology Function and homology informationFunction Domain/homology Component
Regulation of gene expression in early pancreatic precursor cells / pancreas morphogenesis / calcineurin-mediated signaling / acinar cell differentiation / tissue development / bile acid metabolic process / bile acid and bile salt transport / peroxisome proliferator activated receptor binding / transcription regulator inhibitor activity / embryo development ending in birth or egg hatching ... Regulation of gene expression in early pancreatic precursor cells / pancreas morphogenesis / calcineurin-mediated signaling / acinar cell differentiation / tissue development / bile acid metabolic process / bile acid and bile salt transport / peroxisome proliferator activated receptor binding / transcription regulator inhibitor activity / embryo development ending in birth or egg hatching / nuclear thyroid hormone receptor binding / homeostatic process / nuclear retinoid X receptor binding / hormone-mediated signaling pathway / animal organ regeneration / positive regulation of viral genome replication / response to glucose / Notch signaling pathway / transcription coregulator binding / cholesterol metabolic process / SUMOylation of intracellular receptors / cellular response to leukemia inhibitory factor / cholesterol homeostasis / circadian regulation of gene expression / Nuclear Receptor transcription pathway / circadian rhythm / positive regulation of insulin secretion / negative regulation of DNA-binding transcription factor activity / response to organic cyclic compound / RNA polymerase II transcription regulator complex / phospholipid binding / nuclear receptor activity / transcription corepressor activity / sequence-specific double-stranded DNA binding / regulation of cell population proliferation / DNA-binding transcription activator activity, RNA polymerase II-specific / sequence-specific DNA binding / response to ethanol / Estrogen-dependent gene expression / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / DNA-binding transcription factor activity / negative regulation of gene expression / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of gene expression / positive regulation of DNA-templated transcription / chromatin / regulation of DNA-templated transcription / protein-containing complex binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function Nuclear receptor subfamily 0 group B member 1/2 / Nuclear hormone receptor family 5 / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors ... Nuclear receptor subfamily 0 group B member 1/2 / Nuclear hormone receptor family 5 / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Ortlund, E.A. / Yoonkwang, L. / Solomon, I.H. / Hager, J.M. / Safi, R. / Choi, Y. / Guan, Z. / Tripathy, A. / Raetz, C.R.H. / McDonnell, D.P. ...Ortlund, E.A. / Yoonkwang, L. / Solomon, I.H. / Hager, J.M. / Safi, R. / Choi, Y. / Guan, Z. / Tripathy, A. / Raetz, C.R.H. / McDonnell, D.P. / Moore, D.D. / Redinbo, M.R. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2005Title : Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHPAuthors : Ortlund, E.A. / Lee, Y. / Solomon, I.H. / Hager, J.M. / Safi, R. / Choi, Y. / Guan, Z. / Tripathy, A. / Raetz, C.R.H. / McDonnell, D.P. / Moore, D.D. / Redinbo, M.R. History Deposition Feb 13, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 1, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 1.3 Jan 31, 2018 Group : Advisory / Experimental preparationCategory : exptl_crystal_grow / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residuesItem : _exptl_crystal_grow.tempRevision 1.4 Feb 14, 2024 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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