Entry Database : PDB / ID : 1y1u Structure visualization Downloads & linksTitle Structure of unphosphorylated STAT5a ComponentsSignal transducer and activator of transcription 5A Details Keywords SIGNALING PROTEIN / Activator / STAT / DNA-binding / SH2 domain / Transcription regulationFunction / homology Function and homology informationFunction Domain/homology Component
Nuclear signaling by ERBB4 / positive regulation of mast cell differentiation / Interleukin-2 signaling / development of secondary female sexual characteristics / Interleukin-21 signaling / Interleukin-9 signaling / Growth hormone receptor signaling / development of secondary male sexual characteristics / Interleukin-15 signaling / Interleukin-20 family signaling ... Nuclear signaling by ERBB4 / positive regulation of mast cell differentiation / Interleukin-2 signaling / development of secondary female sexual characteristics / Interleukin-21 signaling / Interleukin-9 signaling / Growth hormone receptor signaling / development of secondary male sexual characteristics / Interleukin-15 signaling / Interleukin-20 family signaling / eosinophil differentiation / positive regulation of natural killer cell differentiation / Downstream signal transduction / negative regulation of mast cell apoptotic process / Interleukin-7 signaling / taurine metabolic process / negative regulation of erythrocyte differentiation / Signaling by SCF-KIT / luteinization / positive regulation of mast cell proliferation / myeloid cell apoptotic process / mast cell differentiation / regulation of epithelial cell differentiation / mast cell apoptotic process / mast cell proliferation / negative regulation of T-helper 17 cell lineage commitment / lymphocyte differentiation / natural killer cell differentiation / positive regulation of lymphocyte differentiation / interleukin-7-mediated signaling pathway / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / positive regulation of natural killer cell mediated cytotoxicity / gamma-delta T cell differentiation / Interleukin-3, Interleukin-5 and GM-CSF signaling / positive regulation of gamma-delta T cell differentiation / regulation of steroid metabolic process / interleukin-2-mediated signaling pathway / mammary gland epithelium development / thrombopoietin-mediated signaling pathway / Peyer's patch development / epithelial cell differentiation involved in prostate gland development / negative regulation of myeloid cell apoptotic process / interleukin-5-mediated signaling pathway / reelin-mediated signaling pathway / prostate gland epithelium morphogenesis / lipid storage / mammary gland development / interleukin-15-mediated signaling pathway / cellular response to granulocyte macrophage colony-stimulating factor stimulus / positive regulation of multicellular organism growth / activated T cell proliferation / interleukin-3-mediated signaling pathway / positive regulation of B cell differentiation / natural killer cell mediated cytotoxicity / phosphate ion binding / cellular response to cytokine stimulus / positive regulation of activated T cell proliferation / T cell homeostasis / regulation of multicellular organism growth / positive regulation of blood vessel endothelial cell migration / growth hormone receptor signaling pathway via JAK-STAT / cell surface receptor signaling pathway via JAK-STAT / T cell proliferation / regulation of cell adhesion / lactation / positive regulation of endothelial cell proliferation / positive regulation of T cell proliferation / positive regulation of interleukin-2 production / positive regulation of mitotic cell cycle / B cell differentiation / erythrocyte differentiation / female pregnancy / response to peptide hormone / positive regulation of inflammatory response / cytokine-mediated signaling pathway / T cell differentiation in thymus / mitotic cell cycle / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / sequence-specific DNA binding / transcription by RNA polymerase II / cell population proliferation / RNA polymerase II cis-regulatory region sequence-specific DNA binding / positive regulation of cell population proliferation / regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus / cytosol / cytoplasm Similarity search - Function STAT5a/5b / : / STAT transcription factor, DNA-binding domain / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / : / STAT transcription factor, coiled-coil domain ... STAT5a/5b / : / STAT transcription factor, DNA-binding domain / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / : / STAT transcription factor, coiled-coil domain / STAT protein, DNA binding domain / STAT protein, protein interaction domain / Signal transducer and activator of transcription, linker domain / STAT protein, protein interaction domain / STAT transcription factor, N-terminal domain superfamily / Transcription factor STAT / STAT transcription factor, coiled coil / SH2 domain / SHC Adaptor Protein / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / p53-like transcription factor, DNA-binding / EF-hand / Recoverin; domain 1 / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Up-down Bundle / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.21 Å DetailsAuthors Neculai, D. / Neculai, A.M. / Verrier, S. / Straub, K. / Klumpp, K. / Pfitzner, E. / Becker, S. CitationJournal : J.Biol.Chem. / Year : 2005Title : Structure of the unphosphorylated STAT5a dimerAuthors : Neculai, D. / Neculai, A.M. / Verrier, S. / Straub, K. / Klumpp, K. / Pfitzner, E. / Becker, S. History Deposition Nov 19, 2004 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Oct 4, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.3 Oct 11, 2017 Group : Refinement description / Category : software / Item : _software.classification / _software.nameRevision 1.4 Oct 25, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id
Show all Show less Remark 650 HELIX DETERMINATION METHOD: AUTHOR DETERMINED Remark 700 SHEET DETERMINATION METHOD: AUTHOR DETERMINED