Entry Database : PDB / ID : 1xqs Structure visualization Downloads & linksTitle Crystal structure of the HspBP1 core domain complexed with the fragment of Hsp70 ATPase domain ComponentsHSPBP1 protein Heat shock 70 kDa protein 1 DetailsKeywords CHAPERONE / armadillo repeat / superhelical twistFunction / homology Function and homology informationFunction Domain/homology Component
: / positive regulation of endoribonuclease activity / denatured protein binding / cellular heat acclimation / adenyl-nucleotide exchange factor activity / death receptor agonist activity / negative regulation of inclusion body assembly / : / Viral RNP Complexes in the Host Cell Nucleus / positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ... : / positive regulation of endoribonuclease activity / denatured protein binding / cellular heat acclimation / adenyl-nucleotide exchange factor activity / death receptor agonist activity / negative regulation of inclusion body assembly / : / Viral RNP Complexes in the Host Cell Nucleus / positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway / C3HC4-type RING finger domain binding / positive regulation of microtubule nucleation / ATP-dependent protein disaggregase activity / misfolded protein binding / molecular sequestering activity / regulation of mitotic spindle assembly / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / positive regulation of tumor necrosis factor-mediated signaling pathway / enzyme inhibitor activity / transcription regulator inhibitor activity / aggresome / lysosomal transport / cellular response to steroid hormone stimulus / mRNA catabolic process / regulation of protein ubiquitination / chaperone cofactor-dependent protein refolding / HSF1-dependent transactivation / response to unfolded protein / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / chaperone-mediated protein complex assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / cellular response to unfolded protein / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / ATP metabolic process / inclusion body / vesicle-mediated transport / negative regulation of protein ubiquitination / protein folding chaperone / heat shock protein binding / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / centriole / positive regulation of RNA splicing / positive regulation of erythrocyte differentiation / negative regulation of transforming growth factor beta receptor signaling pathway / positive regulation of protein ubiquitination / positive regulation of interleukin-8 production / AUF1 (hnRNP D0) binds and destabilizes mRNA / G protein-coupled receptor binding / ATP-dependent protein folding chaperone / PKR-mediated signaling / negative regulation of cell growth / histone deacetylase binding / transcription corepressor activity / disordered domain specific binding / unfolded protein binding / virus receptor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein folding / positive regulation of NF-kappaB transcription factor activity / cellular response to oxidative stress / cellular response to heat / protein refolding / vesicle / ficolin-1-rich granule lumen / blood microparticle / receptor ligand activity / protein stabilization / nuclear speck / cadherin binding / ribonucleoprotein complex / negative regulation of cell population proliferation / focal adhesion / signaling receptor binding / centrosome / ubiquitin protein ligase binding / Neutrophil degranulation / positive regulation of gene expression / negative regulation of apoptotic process / perinuclear region of cytoplasm / enzyme binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / ATP hydrolysis activity / protein-containing complex / mitochondrion / RNA binding / extracellular space / extracellular exosome / extracellular region / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Nucleotide exchange factor Fes1 / : / Nucleotide exchange factor Fes1 / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein ... Nucleotide exchange factor Fes1 / : / Nucleotide exchange factor Fes1 / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / ATPase, nucleotide binding domain / ATPase, nucleotide binding domain / Armadillo-like helical / Alpha Horseshoe / Nucleotidyltransferase; domain 5 / Armadillo-type fold / Alpha-Beta Complex / 2-Layer Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.9 Å DetailsAuthors Shomura, Y. / Dragovic, Z. / Chang, H.C. / Tzvetkov, N. / Young, J.C. / Brodsky, J.L. / Guerriero, V. / Hartl, F.U. / Bracher, A. CitationJournal : Mol.Cell / Year : 2005Title : Regulation of Hsp70 Function by HspBP1; Structural Analysis Reveals an Alternate Mechanism for Hsp70 Nucleotide ExchangeAuthors : Shomura, Y. / Dragovic, Z. / Chang, H.C. / Tzvetkov, N. / Young, J.C. / Brodsky, J.L. / Guerriero, V. / Hartl, F.U. / Bracher, A. History Deposition Oct 13, 2004 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Mar 1, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Nov 10, 2021 Group : Database references / Derived calculations / Category : database_2 / struct_ref_seq_dif / struct_siteItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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