Entry Database : PDB / ID : 7d2t Structure visualization Downloads & linksTitle Crystal structure of Rsu1/PINCH1_LIM45C complex ComponentsLIM and senescent cell antigen-like-containing domain protein 1 Ras suppressor protein 1 DetailsKeywords PROTEIN BINDING / Leucine Rich RepeatFunction / homology Function and homology informationFunction Domain/homology Component
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / positive regulation of integrin-mediated signaling pathway / Cell-extracellular matrix interactions / cell-cell junction organization / positive regulation of cell-substrate adhesion / positive regulation of focal adhesion assembly / positive regulation of substrate adhesion-dependent cell spreading / cellular response to transforming growth factor beta stimulus / tumor necrosis factor-mediated signaling pathway / positive regulation of GTPase activity ... Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / positive regulation of integrin-mediated signaling pathway / Cell-extracellular matrix interactions / cell-cell junction organization / positive regulation of cell-substrate adhesion / positive regulation of focal adhesion assembly / positive regulation of substrate adhesion-dependent cell spreading / cellular response to transforming growth factor beta stimulus / tumor necrosis factor-mediated signaling pathway / positive regulation of GTPase activity / establishment of protein localization / cell-cell adhesion / cell-cell junction / positive regulation of canonical NF-kappaB signal transduction / focal adhesion / negative regulation of DNA-templated transcription / positive regulation of gene expression / protein kinase binding / perinuclear region of cytoplasm / signal transduction / zinc ion binding / extracellular exosome / plasma membrane / cytoplasm / cytosol Similarity search - Function : / : / Leucine rich repeat 4 / Leucine Rich repeats (2 copies) / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Leucine-rich repeats, bacterial type ... : / : / Leucine rich repeat 4 / Leucine Rich repeats (2 copies) / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Leucine-rich repeats, bacterial type / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Yang, H. / Wei, Z. / Yu, C. Funding support China, 3items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 31870757 China National Natural Science Foundation of China (NSFC) 31970741 China National Natural Science Foundation of China (NSFC) 31770791 China
CitationJournal : Elife / Year : 2021Title : Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.Authors : Yang, H. / Lin, L. / Sun, K. / Zhang, T. / Chen, W. / Li, L. / Xie, Y. / Wu, C. / Wei, Z. / Yu, C. History Deposition Sep 17, 2020 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Feb 24, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Nov 29, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less