登録情報 | データベース: PDB / ID: 1xoi |
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タイトル | Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide |
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要素 | Glycogen phosphorylase, liver form |
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キーワード | TRANSFERASE / Allosteric enzyme / Glycogen storage disease / glycosyltransferase |
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機能・相同性 | 機能・相同性情報
vitamin binding / purine nucleobase binding / 5-phosphoribose 1-diphosphate biosynthetic process / D-glucose binding / glycogen phosphorylase / glycogen phosphorylase activity / linear malto-oligosaccharide phosphorylase activity / SHG alpha-glucan phosphorylase activity / glycogen catabolic process / bile acid binding ...vitamin binding / purine nucleobase binding / 5-phosphoribose 1-diphosphate biosynthetic process / D-glucose binding / glycogen phosphorylase / glycogen phosphorylase activity / linear malto-oligosaccharide phosphorylase activity / SHG alpha-glucan phosphorylase activity / glycogen catabolic process / bile acid binding / Glycogen breakdown (glycogenolysis) / glycogen metabolic process / AMP binding / necroptotic process / response to bacterium / pyridoxal phosphate binding / glucose homeostasis / secretory granule lumen / ficolin-1-rich granule lumen / Neutrophil degranulation / extracellular exosome / extracellular region / ATP binding / identical protein binding / cytosol / cytoplasm類似検索 - 分子機能 Glycosyl transferase, family 35 / Glycogen/starch/alpha-glucan phosphorylase / Phosphorylase pyridoxal-phosphate attachment site / Carbohydrate phosphorylase / Phosphorylase pyridoxal-phosphate attachment site. / Glycogen Phosphorylase B; / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-288 / N-acetyl-beta-D-glucopyranosylamine / PYRIDOXAL-5'-PHOSPHATE / Glycogen phosphorylase, liver form類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / AB INITIO PHASING / 解像度: 2.1 Å |
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データ登録者 | Wright, S.W. / Rath, V.L. / Gibbs, E.M. / Treadway, J.L. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2005 タイトル: 5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. 著者: Wright, S.W. / Rath, V.L. / Genereux, P.E. / Hageman, D.L. / Levy, C.B. / McClure, L.D. / McCoid, S.C. / McPherson, R.K. / Schelhorn, T.M. / Wilder, D.E. / Zavadoski, W.J. / Gibbs, E.M. / Treadway, J.L. |
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履歴 | 登録 | 2004年10月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2005年4月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.3 | 2017年10月11日 | Group: Refinement description / カテゴリ: software |
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改定 1.4 | 2020年7月29日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / database_PDB_caveat ...chem_comp / database_PDB_caveat / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site / struct_site_gen Item: _chem_comp.name / _entity.pdbx_description ..._chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.5 | 2024年2月14日 | Group: Data collection / Database references / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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