登録情報 データベース : PDB / ID : 1xbo 構造の表示 ダウンロードとリンクタイトル PTP1B complexed with Isoxazole Carboxylic Acid 要素Protein-tyrosine phosphatase, non-receptor type 1 詳細 キーワード HYDROLASE / Protein Tyrosine Phosphatase 1B / PTP1B / Isoxazole Carboxylic Acid機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
PTK6 Down-Regulation / regulation of hepatocyte growth factor receptor signaling pathway / positive regulation of receptor catabolic process / peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity / insulin receptor recycling / negative regulation of vascular endothelial growth factor receptor signaling pathway / positive regulation of IRE1-mediated unfolded protein response / negative regulation of PERK-mediated unfolded protein response / IRE1-mediated unfolded protein response / regulation of intracellular protein transport ... PTK6 Down-Regulation / regulation of hepatocyte growth factor receptor signaling pathway / positive regulation of receptor catabolic process / peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity / insulin receptor recycling / negative regulation of vascular endothelial growth factor receptor signaling pathway / positive regulation of IRE1-mediated unfolded protein response / negative regulation of PERK-mediated unfolded protein response / IRE1-mediated unfolded protein response / regulation of intracellular protein transport / cytoplasmic side of endoplasmic reticulum membrane / sorting endosome / mitochondrial crista / platelet-derived growth factor receptor-beta signaling pathway / regulation of type I interferon-mediated signaling pathway / regulation of endocytosis / positive regulation of protein tyrosine kinase activity / non-membrane spanning protein tyrosine phosphatase activity / peptidyl-tyrosine dephosphorylation / Regulation of IFNA/IFNB signaling / cellular response to unfolded protein / regulation of signal transduction / growth hormone receptor signaling pathway via JAK-STAT / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / negative regulation of signal transduction / Regulation of IFNG signaling / MECP2 regulates neuronal receptors and channels / Growth hormone receptor signaling / endoplasmic reticulum unfolded protein response / negative regulation of MAP kinase activity / positive regulation of JUN kinase activity / negative regulation of insulin receptor signaling pathway / Insulin receptor recycling / ephrin receptor binding / protein dephosphorylation / Integrin signaling / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / protein phosphatase 2A binding / endosome lumen / insulin receptor binding / Negative regulation of MET activity / negative regulation of ERK1 and ERK2 cascade / receptor tyrosine kinase binding / insulin receptor signaling pathway / actin cytoskeleton organization / early endosome / mitochondrial matrix / cadherin binding / protein kinase binding / enzyme binding / endoplasmic reticulum / protein-containing complex / RNA binding / zinc ion binding / cytosol / cytoplasm 類似検索 - 分子機能 Protein-tyrosine phosphatase, non-receptor type-1/2 / : / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif ... Protein-tyrosine phosphatase, non-receptor type-1/2 / : / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性 Chem-IX1 / Tyrosine-protein phosphatase non-receptor type 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Zhao, H. / Liu, G. / Xin, Z. / Serby, M. / Pei, Z. / Szczepankiewicz, B.G. / Hajduk, P.J. / Abad-Zapatero, C. / Hutchins, C.W. / Lubben, T.H. ...Zhao, H. / Liu, G. / Xin, Z. / Serby, M. / Pei, Z. / Szczepankiewicz, B.G. / Hajduk, P.J. / Abad-Zapatero, C. / Hutchins, C.W. / Lubben, T.H. / Ballaron, S.J. / Hassach, D.L. / Kaszubska, W. / Rondinone, C.M. / Trevillyan, J.M. / Jirousek, M.R. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2004タイトル : Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.著者: Zhao, H. / Liu, G. / Xin, Z. / Serby, M.D. / Pei, Z. / Szczepankiewicz, B.G. / Hajduk, P.J. / Abad-Zapatero, C. / Hutchins, C.W. / Lubben, T.H. / Ballaron, S.J. / Haasch, D.L. / Kaszubska, W. ... 著者 : Zhao, H. / Liu, G. / Xin, Z. / Serby, M.D. / Pei, Z. / Szczepankiewicz, B.G. / Hajduk, P.J. / Abad-Zapatero, C. / Hutchins, C.W. / Lubben, T.H. / Ballaron, S.J. / Haasch, D.L. / Kaszubska, W. / Rondinone, C.M. / Trevillyan, J.M. / Jirousek, M.R. 履歴 登録 2004年8月31日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2004年10月19日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2017年10月11日 Group : Refinement description / カテゴリ : software / Item : _software.classification / _software.name改定 1.4 2023年8月23日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_remark / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_remark.text / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
すべて表示 表示を減らす Remark 600 HETEROGEN The ligand, IX1, corresponds to compound 8 of the primary citation of this entry.