activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Release of apoptotic factors from the mitochondria / CD40 receptor complex / SMAC, XIAP-regulated apoptotic response / Regulation of the apoptosome activity / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / intrinsic apoptotic signaling pathway in response to oxidative stress / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / extrinsic apoptotic signaling pathway via death domain receptors ...activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Release of apoptotic factors from the mitochondria / CD40 receptor complex / SMAC, XIAP-regulated apoptotic response / Regulation of the apoptosome activity / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / intrinsic apoptotic signaling pathway in response to oxidative stress / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / extrinsic apoptotic signaling pathway via death domain receptors / intrinsic apoptotic signaling pathway / positive regulation of protein ubiquitination / cytoplasmic side of plasma membrane / mitochondrial intermembrane space / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of canonical Wnt signaling pathway / ubiquitin protein ligase activity / neuron apoptotic process / regulation of cell cycle / positive regulation of apoptotic process / negative regulation of apoptotic process / apoptotic process / mitochondrion / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function
Smac/DIABLO-like superfamily / Smac/DIABLO protein / Second Mitochondria-derived Activator of Caspases / XIAP/BIRC8, UBA domain / : / BIRC2/3-like, UBA domain / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / : / BIR repeat. ...Smac/DIABLO-like superfamily / Smac/DIABLO protein / Second Mitochondria-derived Activator of Caspases / XIAP/BIRC8, UBA domain / : / BIRC2/3-like, UBA domain / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / : / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. / Baculoviral inhibition of apoptosis protein repeat / Zinc finger, C3HC4 type (RING finger) / Death-like domain superfamily / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Baculoviral IAP repeat-containing protein 8 / Diablo IAP-binding mitochondrial protein Similarity search - Component
Biological species
Homo sapiens (human)
Method
X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.7 Å
BaculoviralIAPrepeat-containingprotein8 / Inhibitor of apoptosis-like protein 2 / IAP-like protein 2 / ILP-2 / Testis-specific inhibitor of ...Inhibitor of apoptosis-like protein 2 / IAP-like protein 2 / ILP-2 / Testis-specific inhibitor of apoptosis / XILP2
Mass: 12349.910 Da / Num. of mol.: 6 Source method: isolated from a genetically manipulated source Details: XILP2: HUMAN ILP2 WITH AN N-TERMINAL FUSION (RESIDUES 253-261 FROM HUMAN XIAP) Source: (gene. exp.) Homo sapiens (human) / Gene: BIRC8, ILP2 / Plasmid: pet15b(+) / Species (production host): Escherichia coli / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21DE3 / References: UniProt: Q96P09
#2: Protein/peptide
Diablohomolog, mitochondrial / Second mitochondria-derived activator of caspase / Smac protein / Direct IAP binding protein with low pI
Mass: 726.883 Da / Num. of mol.: 6 / Source method: obtained synthetically Details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in Homo sapiens (human). References: UniProt: Q9NR28
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