- PDB-1x51: Solution structure of the NUDIX domain from human A/G-specific ad... -
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Basic information
Entry
Database: PDB / ID: 1x51
Title
Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform
Components
A/G-specific adenine DNA glycosylase
Keywords
HYDROLASE / DNA BINDING PROTEIN / NUDIX domain / DNA repair / alpha-3 isoform / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
Defective MUTYH substrate binding / Defective MUTYH substrate processing / adenine glycosylase / adenine/guanine mispair binding / depurination / MutSalpha complex binding / purine-specific mismatch base pair DNA N-glycosylase activity / DNA N-glycosylase activity / Displacement of DNA glycosylase by APEX1 / 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity ...Defective MUTYH substrate binding / Defective MUTYH substrate processing / adenine glycosylase / adenine/guanine mispair binding / depurination / MutSalpha complex binding / purine-specific mismatch base pair DNA N-glycosylase activity / DNA N-glycosylase activity / Displacement of DNA glycosylase by APEX1 / 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity / negative regulation of necroptotic process / oxidized purine DNA binding / mismatch repair / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / base-excision repair / 4 iron, 4 sulfur cluster binding / DNA repair / mitochondrion / nucleoplasm / nucleus / metal ion binding Similarity search - Function
Endonuclease III, iron-sulphur binding site / Endonuclease III-like, conserved site-2 / Endonuclease III iron-sulfur binding region signature. / Endonuclease III family signature. / Adenine/Thymine-DNA glycosylase / MutY, C-terminal / NUDIX domain / Helix-hairpin-helix motif / Endonuclease III-like, iron-sulphur cluster loop motif / FES ...Endonuclease III, iron-sulphur binding site / Endonuclease III-like, conserved site-2 / Endonuclease III iron-sulfur binding region signature. / Endonuclease III family signature. / Adenine/Thymine-DNA glycosylase / MutY, C-terminal / NUDIX domain / Helix-hairpin-helix motif / Endonuclease III-like, iron-sulphur cluster loop motif / FES / Helix-hairpin-helix motif / HhH-GPD superfamily base excision DNA repair protein / Helix-hairpin-helix, base-excision DNA repair, C-terminal / HhH-GPD domain / endonuclease III / DNA glycosylase / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homology
Conformer selection criteria: target function,structures with the lowest energy,structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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