登録情報 | データベース: PDB / ID: 1x0h |
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タイトル | Solution structure of the carboxyl-terminal RGC domain in human IQGAP1 |
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要素 | Ras GTPase-activating-like protein IQGAP1 |
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キーワード | SIGNALING PROTEIN / cell adhesion / beta-sandwich / protein-protein interaction / structural genomics / NPPSFA / RIKEN Structural Genomics/Proteomics Initiative / RSGI / National Project on Protein Structural and Functional Analyses |
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機能・相同性 | 機能・相同性情報
negative regulation of dephosphorylation / mitotic actomyosin contractile ring assembly actin filament organization / podocyte development / slit diaphragm / GTPase inhibitor activity / fibroblast migration / MAP-kinase scaffold activity / S100 protein binding / Nephrin family interactions / neuron projection extension ...negative regulation of dephosphorylation / mitotic actomyosin contractile ring assembly actin filament organization / podocyte development / slit diaphragm / GTPase inhibitor activity / fibroblast migration / MAP-kinase scaffold activity / S100 protein binding / Nephrin family interactions / neuron projection extension / RHOV GTPase cycle / cortical actin cytoskeleton / cellular response to platelet-derived growth factor stimulus / RHOC GTPase cycle / RHOQ GTPase cycle / regulation of mitotic cell cycle / phosphatidylinositol-3,4,5-trisphosphate binding / CDC42 GTPase cycle / RHOU GTPase cycle / platelet-derived growth factor receptor signaling pathway / cellular response to epidermal growth factor stimulus / lateral plasma membrane / RHOA GTPase cycle / RAC2 GTPase cycle / positive regulation of protein kinase activity / RHO GTPases activate IQGAPs / fibroblast growth factor receptor signaling pathway / ruffle / regulation of cytokine production / RAC1 GTPase cycle / cellular response to calcium ion / GTPase activator activity / protein serine/threonine kinase activator activity / secretory granule membrane / epidermal growth factor receptor signaling pathway / actin filament / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / cytoplasmic side of plasma membrane / small GTPase binding / actin filament binding / cytoplasmic ribonucleoprotein granule / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / cell migration / cell cortex / basolateral plasma membrane / midbody / protein phosphatase binding / growth cone / microtubule / positive regulation of MAPK cascade / molecular adaptor activity / calmodulin binding / cadherin binding / neuron projection / apical plasma membrane / ribonucleoprotein complex / protein domain specific binding / axon / focal adhesion / calcium ion binding / Neutrophil degranulation / protein kinase binding / signal transduction / extracellular exosome / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 RasGAP protein, C-terminal / RasGAP C-terminus / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain / IQ calmodulin-binding motif / Calponin homology domain ...RasGAP protein, C-terminal / RasGAP C-terminus / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain / IQ calmodulin-binding motif / Calponin homology domain / Calponin homology (CH) domain / Rho GTPase activation protein / Short calmodulin-binding motif containing conserved Ile and Gln residues. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / IQ motif, EF-hand binding site / IQ motif profile. / WW/rsp5/WWP domain signature. / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Saito, K. / Koshiba, S. / Inoue, M. / Kigawa, T. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) |
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引用 | ジャーナル: To be Published タイトル: Solution structure of the carboxyl-terminal RGC domain in human IQGAP1 著者: Saito, K. / Koshiba, S. / Inoue, M. / Kigawa, T. / Yokoyama, S. |
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履歴 | 登録 | 2005年3月23日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2005年9月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2022年3月2日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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改定 1.4 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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