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- PDB-1wit: TWITCHIN IMMUNOGLOBULIN SUPERFAMILY DOMAIN (IGSF MODULE) (IG 18')... -

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Basic information

Entry
Database: PDB / ID: 1wit
TitleTWITCHIN IMMUNOGLOBULIN SUPERFAMILY DOMAIN (IGSF MODULE) (IG 18'), NMR, MINIMIZED AVERAGE STRUCTURE
ComponentsTWITCHIN 18TH IGSF MODULE
KeywordsMUSCLE PROTEIN / IMMUNOGLOBULIN SUPERFAMILY / I SET
Function / homology
Function and homology information


positive regulation of sarcomere organization / positive regulation of locomotion / positive regulation of striated muscle contraction / A band / negative regulation of cell division / behavioral response to nicotine / M band / sarcomere organization / adult locomotory behavior / calmodulin binding ...positive regulation of sarcomere organization / positive regulation of locomotion / positive regulation of striated muscle contraction / A band / negative regulation of cell division / behavioral response to nicotine / M band / sarcomere organization / adult locomotory behavior / calmodulin binding / non-specific serine/threonine protein kinase / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / ATP binding / metal ion binding
Similarity search - Function
: / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily ...: / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Immunoglobulins / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
Biological speciesCaenorhabditis elegans (invertebrata)
MethodSOLUTION NMR
AuthorsFong, S. / Bycroft, M.
Citation
Journal: J.Mol.Biol. / Year: 1996
Title: Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.
Authors: Fong, S. / Hamill, S.J. / Proctor, M. / Freund, S.M. / Benian, G.M. / Chothia, C. / Bycroft, M. / Clarke, J.
#1: Journal: Genetics / Year: 1993
Title: Additional Sequence Complexity in the Muscle Gene, Unc-22, and its Encoded Protein, Twitchin, of Caenorhabditis Elegans
Authors: Benian, G.M. / L'Hernault, S.W. / Morris, M.E.
#2: Journal: Nature / Year: 1989
Title: Sequence of an Unusually Large Protein Implicated in Regulation of Myosin Activity in C. Elegans
Authors: Benian, G.M. / Kiff, J.E. / Neckelmann, N. / Moerman, D.G. / Waterston, R.H.
History
DepositionJun 23, 1996Processing site: BNL
Revision 1.0Dec 23, 1996Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 2, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: TWITCHIN 18TH IGSF MODULE


Theoretical massNumber of molelcules
Total (without water)10,0021
Polymers10,0021
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -MINIMIZED AVERAGE
Representative

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Components

#1: Protein TWITCHIN 18TH IGSF MODULE


Mass: 10002.408 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Caenorhabditis elegans (invertebrata) / Tissue: MUSCLE A-BAND / Cell: MUSCLE CELL / Gene: UNC-22 / Organ: BODY WALL MUSCLE / Plasmid: PRSETC (INVITROGEN) / Gene (production host): UNC-22 / Production host: Escherichia coli (E. coli) / Strain (production host): JM 109 / References: UniProt: Q23551

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR softwareName: X-PLOR / Developer: BRUNGER / Classification: refinement
NMR ensembleConformer selection criteria: MINIMIZED AVERAGE / Conformers submitted total number: 1

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