Entry Database : PDB / ID : 1w45 Structure visualization Downloads & linksTitle The 2.5 Angstroem structure of the K16A mutant of annexin A8, which has an intact N-terminus. ComponentsANNEXIN A8 Details Keywords COAGULATION / ANNEXIN FAMILY / CALCIUM AND PHOSPHOLIPID BINDING PROTEINS / INTACT N-TERMINUS / CXALCIUM AND MEMBRANE- BINDING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of phospholipase A2 activity / negative regulation of serine-type endopeptidase activity / endosome organization / calcium-dependent phospholipid binding / phosphatidylinositol-3,4-bisphosphate binding / endosomal transport / phosphatidylserine binding / phosphatidylinositol-3,4,5-trisphosphate binding / phosphatidylinositol-4,5-bisphosphate binding / sarcolemma ... negative regulation of phospholipase A2 activity / negative regulation of serine-type endopeptidase activity / endosome organization / calcium-dependent phospholipid binding / phosphatidylinositol-3,4-bisphosphate binding / endosomal transport / phosphatidylserine binding / phosphatidylinositol-3,4,5-trisphosphate binding / phosphatidylinositol-4,5-bisphosphate binding / sarcolemma / actin filament binding / blood coagulation / late endosome membrane / collagen-containing extracellular matrix / calcium ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Annexin A8 / Annexin / Annexin repeat, conserved site / Annexin repeat signature. / Annexin / Annexin / Annexin repeats / Annexin repeat / Annexin superfamily / Annexin repeat profile. ... Annexin A8 / Annexin / Annexin repeat, conserved site / Annexin repeat signature. / Annexin / Annexin / Annexin repeats / Annexin repeat / Annexin superfamily / Annexin repeat profile. / Annexin V; domain 1 / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.51 Å DetailsAuthors Rety, S. / Sopkova-de Oliveira Santos, J. / Raguenes-Nicol, C. / Dreyfuss, L. / Blondeau, K. / Hofbauerova, K. / Renouard, M. / Russo-Marie, F. / Lewit-Bentley, A. CitationJournal : J.Mol.Biol. / Year : 2005Title : The Crystal Structure of Annexin A8 is Similar to that of Annexin A3Authors : Rety, S. / Sopkova-De Oliveira Santos, J. / Dreyfuss, L. / Blondeau, K. / Hofbauerova, K. / Raguenes-Nicol, C. / Kerboeuf, D. / Renouard, M. / Russo-Marie, F. / Lewit-Bentley, A. History Deposition Jul 22, 2004 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 18, 2005 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jun 28, 2017 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.typeRevision 1.4 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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