Entry Database : PDB / ID : 1vzo Structure visualization Downloads & linksTitle The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein ComponentsRIBOSOMAL PROTEIN S6 KINASE ALPHA 5 Details Keywords TRANSFERASE / PROTEIN KINASE / PHOSPHORYLATION / SERINE/THREONINE PROTEIN KINASEFunction / homology Function and homology informationFunction Domain/homology Component
histone H3S28 kinase activity / histone H2AS1 kinase activity / positive regulation of CREB transcription factor activity / CREB phosphorylation / histone H3S10 kinase activity / interleukin-1-mediated signaling pathway / negative regulation of cytokine production / regulation of postsynapse organization / ERK/MAPK targets / Recycling pathway of L1 ... histone H3S28 kinase activity / histone H2AS1 kinase activity / positive regulation of CREB transcription factor activity / CREB phosphorylation / histone H3S10 kinase activity / interleukin-1-mediated signaling pathway / negative regulation of cytokine production / regulation of postsynapse organization / ERK/MAPK targets / Recycling pathway of L1 / CD209 (DC-SIGN) signaling / NCAM signaling for neurite out-growth / post-translational protein modification / axon guidance / positive regulation of NF-kappaB transcription factor activity / protein tyrosine kinase activity / non-specific serine/threonine protein kinase / intracellular signal transduction / inflammatory response / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / negative regulation of DNA-templated transcription / regulation of DNA-templated transcription / magnesium ion binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / nucleus / cytoplasm Similarity search - Function Ribosomal protein S6 kinase II / Protein kinase, C-terminal / Protein kinase C terminal domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ... Ribosomal protein S6 kinase II / Protein kinase, C-terminal / Protein kinase C terminal domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Smith, K.J. / Carter, P.S. / Bridges, A. / Horrocks, P. / Lewis, C. / Pettman, G. / Clarke, A. / Brown, M. / Hughes, J. / Wilkinson, M. ...Smith, K.J. / Carter, P.S. / Bridges, A. / Horrocks, P. / Lewis, C. / Pettman, G. / Clarke, A. / Brown, M. / Hughes, J. / Wilkinson, M. / Bax, B. / Reith, A. CitationJournal : Structure / Year : 2004Title : The Structure of Msk1 Reveals a Novel Autoinhibitory Conformation for a Dual Kinase ProteinAuthors : Smith, K.J. / Carter, P.S. / Bridges, A. / Horrocks, P. / Lewis, C. / Pettman, G. / Clarke, A. / Brown, M. / Hughes, J. / Wilkinson, M. / Bax, B. / Reith, A. History Deposition May 21, 2004 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 11, 2004 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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