- PDB-1u70: Understanding the Role of Leu22 Variants in Methotrexate Resistan... -
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基本情報
登録情報
データベース: PDB / ID: 1u70
タイトル
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
要素
Dihydrofolate reductase
キーワード
OXIDOREDUCTASE / variant DHFR mouse / human
機能・相同性
機能・相同性情報
folate reductase activity / Metabolism of folate and pterines / oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor / regulation of removal of superoxide radicals / tetrahydrobiopterin biosynthetic process / tetrahydrofolate metabolic process / response to methotrexate / tetrahydrofolate interconversion / dihydrofolate reductase / dihydrofolate reductase activity ...folate reductase activity / Metabolism of folate and pterines / oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor / regulation of removal of superoxide radicals / tetrahydrobiopterin biosynthetic process / tetrahydrofolate metabolic process / response to methotrexate / tetrahydrofolate interconversion / dihydrofolate reductase / dihydrofolate reductase activity / tetrahydrofolate biosynthetic process / NADP binding / mRNA binding / mitochondrion / nucleus / cytosol / cytoplasm 類似検索 - 分子機能
ジャーナル: Acta Crystallogr.,Sect.D / 年: 2005 タイトル: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with ...タイトル: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. 著者: Cody, V. / Luft, J.R. / Pangborn, W.