- PDB-1u70: Understanding the Role of Leu22 Variants in Methotrexate Resistan... -
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Entry
Database: PDB / ID: 1u70
Title
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
Components
Dihydrofolate reductase
Keywords
OXIDOREDUCTASE / variant DHFR mouse / human
Function / homology
Function and homology information
Metabolism of folate and pterines / regulation of removal of superoxide radicals / dihydrofolic acid binding / tetrahydrobiopterin biosynthetic process / tetrahydrofolate metabolic process / response to methotrexate / tetrahydrofolate interconversion / axon regeneration / dihydrofolate metabolic process / glycine biosynthetic process ...Metabolism of folate and pterines / regulation of removal of superoxide radicals / dihydrofolic acid binding / tetrahydrobiopterin biosynthetic process / tetrahydrofolate metabolic process / response to methotrexate / tetrahydrofolate interconversion / axon regeneration / dihydrofolate metabolic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / tetrahydrofolate biosynthetic process / positive regulation of nitric-oxide synthase activity / response to nicotine / NADP binding / mRNA binding / mitochondrion / nucleus / cytoplasm / cytosol Similarity search - Function
Journal: Acta Crystallogr.,Sect.D / Year: 2005 Title: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Authors: Cody, V. / Luft, J.R. / Pangborn, W.
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