TIM IS A DIMERIC ENZYME. THE COORDINATE LIST CONSISTS OF TWO SUBUNITS (A 2 - A 250, B 2 - B 250). THESE SUBUNITS BELONG TO TWO DIFFERENT DIMERS. THE PGH MOLECULE IS ASSOCIATED WITH (B 2 - B 250). THE COMPLETE DIMERS CAN BE GENERATED WITH CRYSTALLOGRAPHIC TWOFOLDS. (USING THESE CRYSTALLOGRAPHIC TWOFOLDS A COMPLETE UNLIGANDED DIMER AND A COMPLETE PGH-DIMER CAN BE GENERATED. THE FOLLOWING MATRIX RECORDS CAN BE USED TO GENERATE THE DIMERS: -1.000000 0.000000 0.000000 0.00000 0.000000 1.000000 0.000000 0.00000 0.000000 0.000000 -1.000000 0.00000
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Components
#1: Protein
TRIOSEPHOSPHATEISOMERASE
Mass: 26865.832 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Trypanosoma brucei brucei (eukaryote) / Species: Trypanosoma brucei / Strain: brucei / References: UniProt: P04789, triose-phosphate isomerase
Mass: 18.015 Da / Num. of mol.: 61 / Source method: isolated from a natural source / Formula: H2O
Sequence details
RESIDUE ALA 203 IN BOTH CHAINS IS LISTED IN THE SEQUENCE DATABASE AS ARG. RECENT STUDIES HAVE SHOWN ...RESIDUE ALA 203 IN BOTH CHAINS IS LISTED IN THE SEQUENCE DATABASE AS ARG. RECENT STUDIES HAVE SHOWN THIS RESIDUE TO BE ALA.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION
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Sample preparation
Crystal
Density Matthews: 2.73 Å3/Da / Density % sol: 54.93 %
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